STIL Antibodies

AND STIL ELISA kits, STIL Proteins

Many biological assays use antibodies to detect STIL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STIL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STIL antibodies...

We validate the specificity of these antibodies to STIL by testing them on tissues known to express STIL positively and negatively. Browse below to find the STIL antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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STIL Infographic by Boster Bio

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Anti-STIL/SIL Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A04956-1
100 μg/vial

STIL Overview

Facts about SCL-interrupting locus protein.

STIL 3D structure. Source: alphafold

SCL-interrupting locus protein (STIL)

Immediate-early gene. Plays an essential role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution in addition to decreases CDK1 activity correlated with reduced phosphorylation of CDK1.

Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an essential role in the regulation of centriole duplication.

Gene Information

Human
Gene Name:	STIL
Uniprot:	Q15468
Entrez:	6491

Family

Belongs to:

No superfamily

Alternative Names

MCPH7; SCL/TAL1 Interrupting Locus; SCL-Interrupting Locus Protein; SIL; TAL1 (SCL) Interrupting Locus; TAL-1-Interrupting Locus Protein

Molecular Weight

Mass (kDA):
142.955 kDA

Genomic Context


Human

Location:	1p33
Sequence:	1; NC_000001.11 (47250139..47314896, complement)

Tissue Specificity

Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer.

Subcellular Localizations

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Diseases

Leukemia
Acute Lymphocytic Leukemia
Precursor T-cell Lymphoblastic Leukemia-lymphoma
Malignant Neoplasms
Microcephaly
Neoplasms
Primary Microcephaly
Adult T-cell Lymphoma/leukemia
Chromosomal Translocation
Leukemia, T-cell
Infective Disorder
Lymphoma

Lymphoid Leukemia
Neoplasm Metastasis
Carcinoma
Immunologic Deficiency Syndromes
Dysplasia
Hemorrhage
Adenocarcinoma

Interacting Proteins

CENPJ
PLK4
SASS6

Pathways

Cell Cycle
Mitosis
Localization
Transport
Brain Development
Cell Proliferation
Spindle Checkpoint
Neurogenesis
V(d)j Recombination
Spindle Assembly
Pollen Tube Growth
Pathogenesis
Rna Interference

Pollen Germination
Fertilization
Chromosome Separation
Sex Determination
Centriole Replication
Platelet Aggregation
Oviposition

PTMs

Phosphorylation
Dephosphorylation

Methylation
Demethylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STIL

References

PMID: 1922059 by Aplan P.D., et al. Structural characterization of SIL, a gene frequently disrupted in T- cell acute lymphoblastic leukemia.

PMID: 12438740 by Karkera J.D., et al. The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly.