Single-minded homolog 2 Antibodies

AND SIM2 ELISA kits, Single-minded homolog 2 Proteins

Many biological assays use antibodies to detect Single-minded homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Single-minded homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Single-minded homolog 2 antibodies...

We validate the specificity of these antibodies to Single-minded homolog 2 by testing them on tissues known to express SIM2 positively and negatively. Browse below to find the SIM2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SIM2 Infographic by Boster Bio

All SIM2 Products

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Product

Figures

Specificity

Applications

Price

Anti-Single-minded homolog 2 SIM2 Antibody

Human

IHC, WB

$405
Cat # A04436
100ul

SIM2 (NM_009586) Human Over-expression Lysate

Human

$960
Cat # LS006493
100 µg

Anti-SIM2 Antibody Picoband®

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04436-2
100 µg/vial

SIM2 Overview

Facts about Single-minded homolog 2.

SIM2 3D structure. Source: alphafold

Single-minded homolog 2 (SIM2)

Transcription factor that might be a master gene of CNS development in collaboration with Arnt. It may have pleiotropic effects in the tissues expressed during development.

Gene Information

Human
Gene Name:	SIM2
Uniprot:	Q14190
Entrez:	6493

Family

Belongs to:

No superfamily

Alternative Names

human transcription factor SIM2, homolog of the Drosophila single-minded geneSIM110BHLHE15; short isoform; single-minded (Drosophila) homolog 2; single-minded homolog 2 (Drosophila); transcription factor SIM2

Molecular Weight

Mass (kDA):
73.219 kDA

Genomic Context


Human

Location:	21q22.13
Sequence:	21; NC_000021.9 (36699115..36750219)

Subcellular Localizations

Nucleus.

Diseases

Down Syndrome
Neoplasms
Malignant Neoplasms
Nervousness
Prostatic Neoplasms
Trisomy
Malignant Neoplasm Of Prostate
Malignant Neoplasm Of Breast
Hypoxia
Carcinoma
Mammary Neoplasms

Colonic Neoplasms
Neoplasm Invasiveness
Scoliosis, Unspecified
Anoxia
Cell Invasion
Cell Transformation, Neoplastic

Pathways

Pathogenesis
Localization
Brain Development
Neurogenesis
Cell Differentiation
Cell Death
Cell Migration
Gene Silencing
Cell Fate Determination
Mammary Gland Development
Inflammatory Response
Cell Cycle
Regionalization

Cell Proliferation
Gland Development
Lactation
Mitosis
Clathrin-mediated Endocytosis
Stem Cell Differentiation
Hypothalamus Development

PTMs

Ubiquitination

Methylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIM2

References

PMID: 9199934 by Chrast R., et al. Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.

PMID: 8905236 by Osoegawa K., et al. A 19-kb CpG island associated with single-minded gene 2 in Down syndrome chromosomal region.