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STAT2 Antibodies
AND STAT2 ELISA kits, STAT2 Proteins
Many biological assays use antibodies to detect STAT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STAT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STAT2 antibodies...
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STAT2 Infographic by Boster Bio
All STAT2 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA
$480
Cat # EKC1542
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1542
1 kit, containing one 96-well plate and all necessary reagents
Human, Rat
ELISA
$540
Cat # EKC2003
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2003
1 kit, containing two 96-well plates and all necessary reagents
STAT2 Overview
Facts about Signal transducer and activator of transcription 2.
Signal transducer and activator of transcription 2 (STAT2)
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2.
The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to trigger the transcription of interferon stimulated genes, which drive the mobile in an antiviral state (PubMed:9020188, PubMed:23391734).
Gene Information
| Human | |
|---|---|
| Gene Name: | STAT2 |
| Uniprot: | P52630 |
| Entrez: | 6773 |
Family
| Belongs to: |
|---|
| transcription factor STAT family |
Alternative Names
interferon alpha induced transcriptional activator; ISGF-3; MGC59816; P113; signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2, 113kDa; STAT113; STAT2
Molecular Weight
Mass (kDA):
97.916 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.3 |
| Sequence: | 12; NC_000012.12 (56341597..56360161, complement) |
Subcellular Localizations
Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Diseases
- Janiceps
- Virus Diseases
- Neoplasms
- Malignant Neoplasms
- Hepatitis
- Infective Disorder
- Liver Carcinoma
- Hepatitis C
- Leukemia
- Carcinoma
- Liver Neoplasms
- Inflammation
Interacting Proteins
- IFNAR1
- IFNAR2
- IRF9
- STAT1
Pathways
- Pathogenesis
- Localization
- Immune Response
- Cell Growth
- Viral Replication
- Cell Death
- Secretion
- Cell Proliferation
- Cell Cycle
- Virulence
- Innate Immune Response
- Nuclear Import
- Translation
PTMs
- Phosphorylation
- Dephosphorylation
- Acetylation
- Ubiquitination
- Methylation
- Cleavage
Research Areas
- Cancer
- Phospho-Specific
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STAT2
bosterbio.com/bosterbio-gene-info-cards/STAT2
References
PMID: 1502204 by Fu X.-Y., et al. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.
PMID: 7885841 by Yan R., et al. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2.