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- Table of Contents
Facts about Signal transducing adapter molecule 1.
May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase through multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complicated ).
Human | |
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Gene Name: | STAM |
Uniprot: | Q92783 |
Entrez: | 8027 |
Belongs to: |
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STAM family |
DKFZp686J2352; HSE1 Homolog; signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM; STAM1; STAM-1; STAM1STAM-1
Mass (kDA):
59.18 kDA
Human | |
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Location: | 10p12.33 |
Sequence: | 10; NC_000010.11 (17644150..17716824) |
Ubiquitously expressed.
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
PMID: 8780729 by Takeshita T., et al. Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.
PMID: 11687594 by Steen H., et al. Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.