Cohesin subunit SA-1 Antibodies

AND STAG1 ELISA kits, Cohesin subunit SA-1 Proteins

Many biological assays use antibodies to detect Cohesin subunit SA-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cohesin subunit SA-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cohesin subunit SA-1 antibodies...

We validate the specificity of these antibodies to Cohesin subunit SA-1 by testing them on tissues known to express STAG1 positively and negatively. Browse below to find the STAG1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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STAG1 Infographic by Boster Bio

All STAG1 Products

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SA1 (STAG1) (NM_005862) Human Over-expression Lysate

Human

$960
Cat # LS010274
100 µg

Anti-SA1/STAG1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A06471-1
100 µg/vial

STAG1 Overview

Facts about Cohesin subunit SA-1.

STAG1 3D structure. Source: alphafold

Cohesin subunit SA-1 (STAG1)

Part of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.

At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

Gene Information

Human
Gene Name:	STAG1
Uniprot:	Q8WVM7
Entrez:	10274

Family

Belongs to:

SCC3 family

Alternative Names

cohesin subunit SA-1; nuclear protein stromal antigen 1; SA1; stromal antigen 1

Molecular Weight

Mass (kDA):
144.427 kDA

Genomic Context


Human

Location:	3q22.3
Sequence:	3; NC_000003.12 (136336235..136752412, complement)

Subcellular Localizations

Nucleus. Chromosome. Chromosome, centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.

Diseases

Malignant Neoplasms
Neoplasms
Kidney Neoplasm
Carcinoma
Renal Cell Carcinoma
Malignant Neoplasm Of Prostate
Adenocarcinoma
Cell Transformation, Neoplastic
Malignant Paraganglionic Neoplasm
Stomach Neoplasms
Malignant Neoplasm Of Breast
Von Hippel-lindau Syndrome
Neoplasms, Experimental

Cornelia De Lange Syndrome
Endometrial Polyp
Benign Prostatic Hypertrophy
Immunologic Deficiency Syndromes
Cardiovascular Diseases
Tumor Angiogenesis
Lupus Erythematosus, Systemic

Interacting Proteins

PDS5A
PDS5B
SMC3
STAG2
TERF1

Pathways

Sister Chromatid Cohesion
Mitosis
Diplotene
Localization
Dna Replication
Translation
Cell Cycle
Proteolysis
Dna Repair
Metaphase
Chromosome Segregation
Anaphase
Cell Maturation

Regeneration
Cell Death
S Phase
Interphase
Angiogenesis
Chromosome Organization
Pathogenesis

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

Research Areas

Cell Cycle and Replication
DNA Repair
Mitotic Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STAG1

References

PMID: 9305759 by Carramolino L., et al. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs.

PMID: 11076961 by Sumara I., et al. Characterization of vertebrate cohesin complexes and their regulation in prophase.