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- Table of Contents
Facts about Stabilin-2.
May serve to keep tissue integrity by supporting extracellular matrix turnover or it might contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature.
Human | |
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Gene Name: | STAB2 |
Uniprot: | Q8WWQ8 |
Entrez: | 55576 |
Belongs to: |
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No superfamily |
CD44-like precursor FELL; DKFZP434E0321; FAS1 EGF-like and X-link domain containing adhesion molecule-2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 2; FEEL2; FEEL-2; FELE-2; FELL; FELL-2; FEX2; HARE; HAREFELL2; hepatic hyaluronan clearance receptor; Hyaluronan receptor for endocytosis; hyaluronic acid receptor for endocytosis; STAB2; STAB-2; stabilin 2; Stabilin2; Stabilin-2
Mass (kDA):
276.988 kDA
Human | |
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Location: | 12q23.3 |
Sequence: | 12; NC_000012.12 (103587250..103766724) |
Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC- cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Only a small amount appears to be present at the cell surface (PubMed:17145755).
PMID: 11829752 by Politz O., et al. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.
PMID: 12077138 by Adachi H., et al. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities.