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- Table of Contents
Facts about Stabilin-1.
When inhibited in endothelial tube formation assays, there's a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP in the biosynthetic compartment into the endosomal/lysosomal system.
Human | |
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Gene Name: | STAB1 |
Uniprot: | Q9NY15 |
Entrez: | 23166 |
Belongs to: |
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No superfamily |
CLEVER-1; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-1; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 1; FEEL1; FEEL-1; FEEL-1MS-1 antigen; FELE-1; FEX1; KIAA0246common lymphatic endothelial and vascular endothelial receptor-1; MS-1 Antigen; STAB1; STAB-1; stabilin 1; Stabilin1; Stabilin-1
Mass (kDA):
275.482 kDA
Human | |
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Location: | 3p21.1 |
Sequence: | 3; NC_000003.12 (52495338..52524496) |
High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.
Membrane; Single-pass type I membrane protein.
PMID: 11829752 by Politz O., et al. Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.
PMID: 12077138 by Adachi H., et al. FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities.