Protein SSX2 Antibodies

Protein SSX2 (SSX2)

Could act as a modulator of transcription. .

Gene Information

Human
Gene Name:	SSX2
Uniprot:	Q16385
Entrez:	6757

Family

Belongs to:
SSX family

Alternative Names

Cancer/testis antigen 5.2; cancer/testis antigen family 5, member 2a; CT5.2a; HD21; HOM-MEL-40; MGC119055; MGC15364; MGC3884; protein SSX2; sarcoma, synovial, X-chromosome-related 2; SSX; SSX2A; SSX2B; synovial sarcoma, X breakpoint 2B; synovial sarcoma, X breakpoint 2CT5.2; Tumor antigen HOM-MEL-40

Molecular Weight

Mass (kDA):
21.62 kDA

Genomic Context

Human
Location:	Xp11.22
Sequence:	X; NC_000023.11 (52696896..52707227, complement)

Tissue Specificity

Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.

Subcellular Localizations

Nucleus.

Diseases

• Neoplasms
• Sarcoma
• Synovial Sarcoma
• Malignant Neoplasms
• Melanoma
• Chromosomal Translocation
• Soft Tissue Neoplasms
• Malignant Paraganglionic Neoplasm
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Carcinoma
• Testicular Neoplasms

• Mammary Neoplasms
• Skin Neoplasms
• Malignant Squamous Cell Neoplasm
• Cell Transformation, Neoplastic
• Lung Neoplasms
• Malignant Neoplasm Of Lung

Interacting Proteins

• BLZF1
• KRT40
• MAGEC2
• RAB3IP
• SSX2IP

• SYCE1
• TAX1BP1
• ZBED1

Pathways

• Localization
• Cell Proliferation
• Reverse Transcription
• Immune Response
• Pathogenesis
• Mitosis
• Metaphase
• Humoral Immune Response
• Cell Growth
• Interphase
• Chromatin Remodeling
• Oncogenesis
• Cell Adhesion

• Hypersensitivity
• Ossification
• Methylation
• Cell Division
• Fermentation
• Metaplastic Ossification
• Mesenchymal To Epithelial Transition

PTMs

• Demethylation
• Methylation

• Phosphorylation
• Cleavage

Research Areas

• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SSX2

Synovial Sarcoma X Breakpoint 2 - The Best Uses Of The SSX2 Marker

We will be covering the basics of Synovial sarcoma X breakpoint 2, SSX2, Steven Boster's story, and the history of Synovial sarcoma X. We will also examine the history of SSX2, a protein that is associated with synovial sarcoma. And the best uses for this marker. Once we understand these facts, we will be able SSX2 to better comprehend the disease's development.

Synovial sarcoma X breakpoint 2

Synovial sarcoma X, breakpoint 2 (SSX2) can be found in the synoviums of many animals. This gene is thought to act as a transcription regulator and has been linked to the development of the disease. It is located in the testis and thyroid and is highly expressed in the tissues. It is expressed in two different forms that can be separated using alternative splicing. SSX2 (isoform 2) has a longer sequence of proteins than isoform 1. It is suitable to be used for Western blotting.

Synovial cancer affects the tissue around the joints. The best way to treat it is to detect it early. Its symptoms can be spotted early, which can prolong a person's life. Synovial sarcoma is diagnosed in approximately one to two Americans each year. Synovial sarcoma is slow growing so early diagnosis is crucial to ensure survival. Although rare in adults it affects around 1,000 people per year. It is more common in males than in females.

90% of SS tumors have the SYT–SSX mutation. SSX is also found in cancers of other soft tissues, and has an unspecific immunohistochemistry profile. Because of this, it is crucial to confirm the diagnosis by performing molecular testing. Because 90% of SS carry t(X;18)(p11.2;q11.2), this gene can be used to screen patients for synovial sarcoma.

This cell line was established for 11 months and subcultured up until 15 times. SS18-SSX's polygonal shape is what makes it stand out. It can also form a spheroid if seeded on dishes with low attachment. The NCC-SS2-C1 cell line was established from primary tumor tissue. The cell line has been used in a variety of researches to discover the molecular basis of synovial arcoma.

Antibody SSX2

Synovial sarcoma, X breakpoint 2, or SSX2 for short, is a highly homologous protein in the family of Kruppel-type zinc finger proteins. Boster Bio's SSX2 marker contains the Kruppel associated box domain (KAB), a conserved peptide domain that is only found in certain types zinc finger proteins.

Boster Bio SSX2 vaccine is made with MIP SSX2 to protect mice from a syngeneic sarcoma threat. MIP SSX2 immunization results is enhanced antigen-specific CTL response. Antigen-specific CD8 T cells from mice immunized with MIP-SSX2 were found to have cytolytic activity against syngeneic sarcoma cells.