This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
SSTR2 Antibodies
AND SSTR2 ELISA kits, SSTR2 Proteins
Many biological assays use antibodies to detect SSTR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SSTR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SSTR2 antibodies...
Previous: CBLIF
Next: SSTR3
SSTR2 Infographic by Boster Bio
All SSTR2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M01689
100 μl
Cat # M01689
100 μl
Human
$628
Cat # LS006752
100 µg
Cat # LS006752
100 µg
SSTR2 Overview
Facts about Somatostatin receptor type 2.
Somatostatin receptor type 2 (SSTR2)
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels.
Gene Information
| Human | |
|---|---|
| Gene Name: | SSTR2 |
| Uniprot: | P30874 |
| Entrez: | 6752 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
Smstr2; Somatostatin R2; somatostatin receptor 2; somatostatin receptor type 2; SomatostatinR2; SRIF-1; SS2R; SS-2-R; SS2-R; SST2; SSTR2
Molecular Weight
Mass (kDA):
41.333 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.1 |
| Sequence: | 17; NC_000017.11 (73165010..73176633) |
Tissue Specificity
Expressed in both pancreatic alpha- and beta- cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cytoplasm. Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Diseases
- Neoplasms
- Pituitary Diseases
- Malignant Neoplasms
- Adenoma
- Carcinoma
- Pituitary Neoplasms
- Pancreatic Neoplasm
- Pituitary Adenoma
- Neuroendocrine Tumors
- Pertussis
- Acromegaly
- Neoplasm Metastasis
Interacting Proteins
- PIK3R1
- SSTR3
Pathways
- Secretion
- Cell Proliferation
- Localization
- Hormone Secretion
- Cell Growth
- Acid Secretion
- Insulin Secretion
- Gastric Acid Secretion
- Angiogenesis
- Cell Cycle
- Growth Hormone Secretion
- Glucagon Secretion
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Cleavage
- Demethylation
Research Areas
- Alzheimers Research
- Cancer
- GPCR
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SSTR2
bosterbio.com/bosterbio-gene-info-cards/SSTR2
References
PMID: 1346068 by Yamada Y., et al. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
PMID: 10619399 by Petersenn S., et al. Genomic structure and transcriptional regulation of the human somatostatin receptor type 2.
1 Publications of Boster SSTR2 Antibodies & ELISA Kits
- PubMed ID: 28810643, Li M, Wang S, Wang S, Zhang L, Wu D, Yang R, Ji A, Li Y, Wang J. Exp Ther Med. 2...
*More publications can be found for each product on its corresponding product page