Somatostatin Antibodies

Somatostatin (SST)

Somatostatin inhibits the release of somatotropin. .

Gene Information

Human
Gene Name:	SST
Uniprot:	P61278
Entrez:	6750

Family

Belongs to:
somatostatin family

Alternative Names

Growth hormone release-inhibiting factor; SMST; SOM; Somatostatin; somatostatin-14; somatostatin-28; SRIF; SST

Molecular Weight

Mass (kDA):
12.736 kDA

Genomic Context

Human
Location:	3q27.3
Sequence:	3; NC_000003.12 (187668912..187670394, complement)

Subcellular Localizations

Secreted.

Diseases

• Neoplasms
• Malignant Neoplasms
• Pituitary Diseases
• Pain
• Neuroendocrine Tumors
• Carcinoma
• Adenoma
• Pituitary Neoplasms
• Pancreatic Neoplasm
• Carcinoid Tumor
• Neoplasm Metastasis
• Pituitary Adenoma
• Pathologic Neovascularization

• Inflammation
• Acromegaly
• Depressive Disorder
• Diabetes Mellitus
• Nervousness
• Adenocarcinoma
• Schizophrenia

Pathways

• Secretion
• Localization
• Cell Proliferation
• Transport
• Cell Growth
• Hormone Secretion
• Angiogenesis
• Insulin Secretion
• Cell Cycle
• Sperm Storage
• Pathogenesis
• Acid Secretion
• Cell Death

• Endocytosis
• Insemination
• Excretion
• Glucagon Secretion
• Gastric Acid Secretion
• Translation
• Cognition

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Reduction
• Glycosylation
• Dephosphorylation

• Acylation
• Iodination
• Demethylation
• Oxidation
• Carboxylation
• Ribosylation

• Deglycosylation

Research Areas

• Breast Cancer
• Cancer
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SST

The Boster Bio: Best Uses Of The SST Marker

Boster Bio is a biosensor that you may have heard of. It measures the level of population or the specific species. The SST Marker measures this, and provides a way to compare and the two measurements. This biosensor can be used by Boster scientists for applications and studies on specific species. Additionally, Boster Bio offers product credits for their research. This marker is accessible to all scientists and the advantages and applications it provides are universally applicable.

Benefits

The SST marker has many benefits. It can be used for internal heterogeneity detection in the SST population. These benefits include improving the social skills and peer relationships of students who have LDs. The SST marker is a powerful tool for detecting and treating LDs. Numerous studies have proven that SST programs can enhance social skills and improve peer relationships for students who suffer from LDs. Please refer to the benefits and other information on SST.

SST provides reliable and high-quality delivery by semantically combining datagrams and streams. This eliminates the "large datagram" problem. The risk of losing datagram fragments increases exponentially with the increasing fragmentation. Additionally, SST allows applications to prioritize streams and adjust the priority dynamically using out-of-band signaling. A prototype for user-space SST confirms that SST is TCP compatible within twofold range. Its performance on WiFi networks is comparable with the performance of kernel TCP or TCP for users in user space.

SST ensures reliability within streams, but not between streams. It can be used as a best-effort datagram transport because it doesn't require long-term state retention after closing. It allows applications to create multiple streams at once while ensuring that they will respond in the most efficient manner. Applications can take data at different rates because each stream has its own flow control. They can continuously accept data on one stream , but temporarily blocking the sender on the other.

SST helps students build positive relationships with their peers and improve their social skills. These skills can be developed through the SST and aid students in learning to manage difficult situations. It is particularly beneficial for adolescents and children who have LDs. It can also be used to aid adults and children who have LDs from toddlers up to adults. It is a good tool for adults and classrooms. SST also has other benefits.

Images

A quantitative analysis of SST colocalization was conducted using images taken from sections of 40x from five different animals. Two of these slices were acute, corresponding to 300 mm in thickness. These images revealed that SST was colocalized with YFP in the hip and cortex of P30 animals. These findings suggest that SST is a crucial component in visual perception. These images may offer therapeutic benefits in the treatment sensory perception or visual cognition problems.

SST neuropeptide also blocks excitatory neurotransmitters that are released from PV+ interneuron cell cells. SST plays a crucial role in modulating the visual gain of V1 microcircuits and suppresses excitatory synaptic transmitting on PV+ neurons. This results in better vision in mice. The analysis of images of the SST Marker has also revealed that this neuropeptide inhibits release of excitatory neurotransmitters in the PV+ retina.

Validation

Specific proteins and peptides are produced by inhibitory interneurons. The three biochemical markers responsible for eighty to ninety percent of inhibitory cells in mice were discovered. These markers include parvalbumin, vasoactive intestinal peptide. The brain's SST marker is involved in a myriad of biochemical pathways which include those involved in memory and learning. In addition, these neurons are vital for mood regulation.

ImageJ cell counter plugins were used to quantify SSTRs in INs. In order to determine the immunostaining properties of interneurons, the plugins identified the boundaries between L1/L2/3, L4/L5/6 and L3/L4. Additionally, the immunoreactivity of SSTR4 was greater in the barrel cortex L2/3, L2/3, and L5.

Applications

A variety of applications protocols, including internet telephony, require out-of-band signaling. This was traditionally accomplished using ad-hoc strategies. Sometimes the multiple UDP media sessions can be caused by a lack of transport layer support. Instead of setting up two separate streams, applications can connect out-of-band signals to the parent stream. SST is TCP-friendly to 2 degrees and is comparable to kernel TCP and user-space on WiFi networks.

Neurons with SST markers show high set points for firing. They are key gatekeepers of plasticity, information flow within the local network, and perform other vital functions. This marker has numerous uses. To better understand the role played by SST neurons in various disorders, we must understand the anatomical and functional characteristics of these neurons. This marker is particularly useful in analyzing cortical neuronal circuits. The SST marker has recently been found in cortical slices.

The SST protocol borrows many concepts from IPsec, including the connection state and the packet security model. The SST protocol uses channels and packet sequence numbers inspired by IPsec's security associations. Additionally, it employs an extremely light 32-bit authenticator in place of the cryptographic MAC to prevent stale and replayed packets. Despite the simplicity of the protocol, it is able to provide security that is comparable to other unsecure Internet transports.

Refer to

The SST marker is responsible for many functions that include controlling the activity of axonal neurons within glia. It inhibits the influx of calcium into cells that results in a decrease of the excitability of these cells. The effect of it on axonal trafficking and signaling is also investigated. However, the functions of the SST aren't clear. The SST Marker has been inconsistently used, with conflicting results being reported.

These neurons comprise 30 percent of the total number of interneurons found in many brain regions. They are found throughout the hippocampusand neocortex and also have synaptic connections with nearly every neighboring pyramidal cells. This means that these neurons are highly organized, with distinct wiring patterns. Although many of their connections are very general, there are some that have specific wiring patterns while others might not be relevant to their function.