SSH1 Antibodies

AND SSH1 ELISA kits, SSH1 Proteins

Many biological assays use antibodies to detect SSH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SSH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SSH1 antibodies...

We validate the specificity of these antibodies to SSH1 by testing them on tissues known to express SSH1 positively and negatively. Browse below to find the SSH1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SSH1 Infographic by Boster Bio

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Anti-SSH1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A03480
100 µg/vial

SSH1 Overview

Facts about Protein phosphatase Slingshot homolog 1.

SSH1 3D structure. Source: alphafold

Protein phosphatase Slingshot homolog 1 (SSH1)

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and arouses their disassembly.

Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. .

Gene Information

Human
Gene Name:	SSH1
Uniprot:	Q8WYL5
Entrez:	54434

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

EC 3.1.3.16; EC 3.1.3.48; FLJ21928; hSSH-1L; KIAA1298FLJ38102; protein phosphatase Slingshot homolog 1; slingshot 1; slingshot homolog 1 (Drosophila); SSH1L; SSH-1L; SSH-like protein 1

Molecular Weight

Mass (kDA):
115.511 kDA

Genomic Context


Human

Location:	12q24.11
Sequence:	12; NC_000012.12 (108778191..108857606, complement)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

Diseases

Porokeratosis, Disseminated Superficial Actinic
Neoplasms
Malignant Neoplasms
Protrusion
Tissue Adhesions
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Liver Carcinoma
Cell Invasion
Stomach Neoplasms
Mutation, Out-of-frame
Neoplasm Invasiveness

Carcinoma
Endometriosis, Site Unspecified
Posttransfusion Purpura
Mammary Neoplasms
Osteoporosis
Cold Intolerance

Interacting Proteins

CFL1
CORO1B
LIMK1
YWHAB
YWHAQ

Pathways

Cell Migration
Localization
Rna Interference
Cell Motility
Keratinization
Wound Healing
Keratinocyte Migration
Pathogenesis
Transport
Synaptic Transmission
Protein Phosphorylation
Cell Adhesion
Osteoclast Differentiation

Muscle Cell Migration
Axon Regeneration
Virulence
Chromosome Segregation
Myelination
Cytokinesis
Mitochondrial Dna Replication

PTMs

Phosphorylation
Dephosphorylation

Oxidation
Cleavage

Glycosylation

Research Areas

Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SSH1

References

PMID: 11832213 by Niwa R., et al. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.

PMID: 14531860 by Ohta Y., et al. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin.