SPTBN1 Antibodies

AND SPTBN1 ELISA kits, SPTBN1 Proteins

Many biological assays use antibodies to detect SPTBN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPTBN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPTBN1 antibodies...

We validate the specificity of these antibodies to SPTBN1 by testing them on tissues known to express SPTBN1 positively and negatively. Browse below to find the SPTBN1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPTBN1 Infographic by Boster Bio

All SPTBN1 Products

Product

Figures

Specificity

Applications

Price

Anti-SPTBN1 Antibody

1 Q&As

Human, Mouse, Rat

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # A03164
100ul

Anti-Spectrin beta II SPTBN1 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$380
Cat # A03164-2
100ul

SPTBN1 (NM_003128) Human Over-expression Lysate

Human

$960
Cat # LS006711
100 µg

SPTBN1 Overview

Facts about Spectrin beta chain, non-erythrocytic 1.

SPTBN1 3D structure. Source: alphafold

Spectrin beta chain, non-erythrocytic 1 (SPTBN1)

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. .

Gene Information

Human
Gene Name:	SPTBN1
Uniprot:	Q01082
Entrez:	6711

Family

Belongs to:

spectrin family

Alternative Names

beta-fodrin; beta-G spectrin; Beta-II spectrin; beta-spectrin 2; beta-spectrin II; betaSpII; ELF; embryonic liver beta-fodrin; Fodrin beta chain; spectrin beta chain, brain 1; spectrin, beta, non-erythrocytic 1; Spectrin, non-erythroid beta chain 1; SPTB2

Molecular Weight

Mass (kDA):
274.609 kDA

Genomic Context


Human

Location:	2p16.2
Sequence:	2; NC_000002.12 (54456327..54671446)

Tissue Specificity

Isoform 2 is present in brain, lung and kidney (at protein level).

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line. Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Diseases

Neoplasms
Fracture
Malignant Neoplasms
Osteoporosis
Osteoporotic Fractures
Carcinoma
Neoplastic Syndromes, Hereditary
Malignant Neoplasm Of Pancreas
Cytogenetic Abnormality
Myeloproliferative Disease
Retinal Dystrophies
Neoplasm Metastasis

Primary Congenital Glaucoma
Atypical Chronic Myeloid Leukemia
Ovarian Serous Adenocarcinoma
Neoplasms, Experimental
Myeloid Leukemia, Chronic
Dyslexia

Interacting Proteins

CDC5L
DISC1
SPTA1
SPTAN1

Pathways

Localization
Ossification
Pathogenesis
Cell Adhesion
Osteoclast Differentiation
Cell Activation
Cell Migration
Cell Proliferation
Endochondral Ossification
Stem Cell Differentiation
T Cell Activation
Mitosis
Proteolysis

Dna Repair
Membrane Biogenesis
Myelination
Drug Resistance
Mesenchymal Stem Cell Differentiation
Reverse Transcription
Regulation Of Cell Proliferation

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPTBN1

References

PMID: 1527002 by Hu R.J., et al. Characterization of human brain cDNA encoding the general isoform of beta-spectrin.

PMID: 11665863 by Chen Y., et al. A novel isoform of beta-spectrin II localizes to cerebellar Purkinje- cell bodies and interacts with neurofibromatosis type 2 gene product schwannomin.