SPINT2 Antibodies

Kunitz-type protease inhibitor 2 (SPINT2)

Inhibitor of HGF activator.

Also inhibits plasmin, tissue and plasma kallikrein, and factor XIa.

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Gene Information

Human
Gene Name:	SPINT2
Uniprot:	O43291
Entrez:	10653

Family

Belongs to:
No superfamily

Alternative Names

HAI2; HAI-2; HAI-2DIAR3; HAI2FLJ45571; Hepatocyte growth factor activator inhibitor type 2; Kop; kunitz-type protease inhibitor 2; PB; Placental bikunin; serine peptidase inhibitor, Kunitz type, 2; serine protease inhibitor, Kunitz type, 2

Molecular Weight

Mass (kDA):
28.228 kDA

Genomic Context

Human
Location:	19q13.2
Sequence:	19; NC_000019.10 (38264573..38292615)

Tissue Specificity

Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Neoplasms
• Malignant Neoplasms
• Cell Invasion
• Neoplasm Metastasis
• Carcinoma
• Inflammation
• Ovarian Neoplasm
• Malignant Neoplasm Of Ovary
• Neoplasm Invasiveness
• Kidney Calculi
• Proteinuria Of Undiagnosed Cause
• Liver Carcinoma
• Kidney Diseases

• Malignant Paraganglionic Neoplasm
• Liver Neoplasms
• Urolithiasis
• Systemic Infection
• Kidney Neoplasm
• Tissue Adhesions
• Epithelial Ovarian Cancer

Pathways

• Excretion
• Secretion
• Localization
• Proteolysis
• Methylation
• Pathogenesis
• Glomerular Filtration
• Transport
• Ovulation
• Sulfation
• Cell Proliferation
• Glycosylation
• Translation

• Regeneration
• Reverse Transcription
• Demethylation
• Cell Growth
• Cell Migration
• Acute-phase Response
• Cell Motility

PTMs

• Cleavage
• Phosphorylation
• Methylation
• Glycosylation

• Demethylation
• Deglycosylation
• Sulphation
• Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPINT2

Boster Bio: Best Uses Of The SPINT2 Marker

This article will introduce you to Steven Boster, the inventor of the SPINT2 marker. Find out more about his history, current projects, as well as future plans. You can also use this information to get the most out of your SPINT2 experiment. We will also discuss the best use of this device. This article is relevant for scientists around the world. Find out more about Boster Bio. Best Uses For The SPINT2 marker

Historie

Recent research found that SPINT2 gene expression is associated with poorer outcomes for OC patients. This association was also observed in two independent metaanalyses. However, a large portion of patients with OC aren't positive for SPINT2 gene expression. These findings are currently being investigated further. This research could also lead a discovery of novel functions in SPINT2.

The study shows that SPINT2 mutations do not exist in all non-sCSD patients. One non-sCSD splice mutation was found in #14, a non-sCSD splice patient. This heterozygous splice is identical to the five sCSD families. The heterozygous variant of the splice mutation can be correlated with sodium status. Therefore, it may not be possible to identify carriers without testing for specific markers.

Other studies suggest that SPINT2 could play a role in the progression of ovarian carcinoma. Its association with survival has also been suggested. Other studies have also shown that SPINT2 is linked to a variety pathomechanisms. These include hepatocyte Growth Factor (HGF), activator (ATR). Inhibiting this enzyme can cause the body to produce pro-tumorigenic (active) HGF.

Current projects

SPINT2 Marker, a highly expressed protein that has been implicated in several types of cancer, is highly expressed. Studies of its involvement in cancer development and progression have focused on the biological, functional, and clinical aspects of this protein. Among other things, SPINT2 is important for intestinal ionic homeostasis, which is crucial for the absorption of sodium. SPINT2 mutations are associated with congenital salt diarrhea in humans.

Future plans

Hypomorphic mutations in the SPINT2 gene result in a wide range of organogenesis abnormalities, including cleft palate, hamartoma, and atresia. These changes in the gene can have severe developmental consequences. Future plans for SPINT2 are to examine the effects of hypomorphic variants in human embryos. Researchers are currently conducting several studies to assess the effects hypomorphic mutations have on human development.