Spindlin-1 (SPIN1)

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated in'Lys-4' and asymmetrically dimethylated in'Arg-8' (H3K4me3 and H3R8me2a) and functions as an activator of Wnt signaling pathway downstream of PRMT2. In the event of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551).

Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006).