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- Table of Contents
1 Citations 1 Q&As
Facts about Sphingosine kinase 1.
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Human | |
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Gene Name: | SPHK1 |
Uniprot: | Q9NYA1 |
Entrez: | 8877 |
Belongs to: |
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No superfamily |
EC 2.7.1.91; SK1; sphingosine kinase 1; SPHK1; SPHKSK 1; SPK 1; SPK; SPK1
Mass (kDA):
42.518 kDA
Human | |
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Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (76383204..76387855) |
Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.
Cytoplasm. Nucleus. Cell membrane. Endosome membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Cell junction, synapse. Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner (PubMed:19854831). Binds to membranes containing negatively charged lipids but not neutral lipids (PubMed:24929359). Recruited to endocytic membranes by sphingosine where promotes membrane fusion (By similarity).
PMID: 10863092 by Melendez A.J., et al. Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution.
PMID: 10802064 by Nava V.E., et al. Functional characterization of human sphingosine kinase-1.
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