SGPL1 Antibodies

AND SGPL1 ELISA kits, SGPL1 Proteins

Many biological assays use antibodies to detect SGPL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SGPL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SGPL1 antibodies...

We validate the specificity of these antibodies to SGPL1 by testing them on tissues known to express SGPL1 positively and negatively. Browse below to find the SGPL1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN4 Next: FUBP1

SGPL1 Infographic by Boster Bio

All SGPL1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-SGPL1 Antibody

Human, Mouse, Rat

$405
Cat # A04661
100ul

SGPL1 (NM_003901) Human Over-expression Lysate

Human

$628
Cat # LS008879
100 µg

SGPL1 Overview

Facts about Sphingosine-1-phosphate lyase 1.

SGPL1 3D structure. Source: alphafold

Sphingosine-1-phosphate lyase 1 (SGPL1)

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Gene Information

Human
Gene Name:	SGPL1
Uniprot:	O95470
Entrez:	8879

Family

Belongs to:

group II decarboxylase family

Alternative Names

EC 4.1.2.27; FLJ13811; hSPL; KIAA1252; S1PL; SGPL1; Sphingosine-1-phosphate aldolase; sphingosine-1-phosphate lyase 1; SPL; SPLSPL 1; SP-lyase 1; SP-lyase

Molecular Weight

Mass (kDA):
63.524 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (70815920..70881184)

Tissue Specificity

Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343).

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.

Diseases

Neoplasms
Disease Of Adrenal Medulla
Dermatitis
Cell Transformation, Neoplastic
Malnutrition
Melanoma
Neurodegenerative Disorders
Dermatitis, Atopic
Endometrial Polyp
Atrophy
Malignant Paraganglionic Neoplasm
Nose Neoplasms
Carcinogenesis

Endometriosis, Site Unspecified
Ovarian Diseases
Tumor Angiogenesis
Malignant Neoplasms
Lymphopenia
Nervousness
Decreased Immunologic Activity [pe]

Interacting Proteins

TMEM173

Pathways

Cell Proliferation
Cell Growth
Neurogenesis
Angiogenesis
Pathogenesis
Oncogenesis

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SGPL1

References

PMID: 11018465 by Van Veldhoven P.P., et al. Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22.

PMID: 14570870 by Reiss U., et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.