Transcription factor Sp7 Antibodies

Transcription factor Sp7 (SP7)

Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).

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Gene Information

Human
Gene Name:	SP7
Uniprot:	Q8TDD2
Entrez:	121340

Family

Belongs to:
Sp1 C2H2-type zinc-finger protein family

Alternative Names

MGC126598; Osterix; OSX; OSXosterix; Sp7 transcription factor; Sp7; transcription factor Sp7; Zinc finger protein osterix

Molecular Weight

Mass (kDA):
44.994 kDA

Genomic Context

Human
Location:	12q13.13
Sequence:	12; NC_000012.12 (53326575..53344793, complement)

Tissue Specificity

Restricted to bone-derived cell.

Subcellular Localizations

Nucleus.

Diseases

• Fracture
• Bone Diseases
• Osteoporosis
• Neoplasms
• Multiple Myeloma
• Osteogenesis Imperfecta
• Hypertrophy
• Osteosarcoma
• Malignant Paraganglionic Neoplasm
• Dental Plaque
• Tissue Adhesions
• Atherosclerosis
• Pneumonia

• Bone Neoplasms
• Osteopenia
• Craniosynostosis
• Physiological Stress
• Degenerative Polyarthritis
• Calcinosis
• Osteoid Osteoma

Pathways

• Osteoblast Differentiation
• Nitrogen Fixation
• Cell Differentiation
• Cell Proliferation
• Ossification
• Regeneration
• Bone Development
• Chondrocyte Differentiation
• Transport
• Chemotaxis
• Localization
• Secretion
• Flocculation

• Pathogenesis
• Cell Growth
• Regulation Of Osteoblast Differentiation
• Bone Remodeling
• Bone Resorption
• Colony Morphology
• Osteoblast Proliferation

PTMs

• Phosphorylation
• Nitration
• Oxidation
• Methylation
• Sumoylation

• Hydroxylation
• Amidation
• Acetylation
• Ribosylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP7

Best Uses Of The SP7 Marker

The SP7 gene is a master regulator of bone formation. It also regulates RIOX1 and interacts with RNA helicase A. This gene is available to scientists worldwide, regardless of its application. Continue reading to learn more about the SP7 gene. Don't forget about submitting your results! You can earn product points for the work done!

Sp7 acts as a master regulator of bone formation

The human osteoblast cell line contains SP7, a transcription element that coordinates changes to gene expression necessary for bone formation. The SP7 genes is also expressed by chondrocytes. It is composed of two promoters that generate two alternatively spliced isoforms. The proximal promor generates full-length protein while the distal one yields the short form. This short protein is more abundant.

The SP7 genes is a master regulator in bone formation. It regulates both embryonic growth and homeostasis. It may also play an important role in neuronal growth. It is involved with osteoblast differentiation as well as osteosarcomas. Sp7 is expressed in osteosarcoma cells from rats and humans. A few human osteosarcomas include an amplification in SP7 at chromosome 12q13-15. This region is linked to bone development.

The SP7 gene is an osteoblast differentiation factor. Its activities positively regulate osteoblast formation. Osteoblast differentiation is key to regulating endochondral and saline ossification in both mice and humans. This gene could be used to treat bone disorders in humans. More research is needed to understand the role of SP7 and osteoblast differentiation. These two genes may provide a pathway toward treating osteoporosis, fractures, and other bone disorders.

The human SP7 genes span 9.7 kb. It also contains three exons. Two of them can be alternatively sequenced. Sp7 cDNAs encode a full-length protein, an aminoterminally truncated, and a shorter isoform. This gene belongs to SP/XKLF. Multiple functional studies have shown that Sp7 is an osteoblast differentiation marker.

The SP7 gene may also be associated with recessive bone imperfecta (ROI), a type genetic disease. Recessive OI, a genetic disorder that causes bone degeneration and low bone turnover, is an inherited condition. Patients with a frameshift mutant in the SP7 genetic gene may experience problems with their bones. Researchers are looking into gene therapy for OI.

SP7, in addition to being a bone derived protein has been found to be crucial for the development and maintenance of skeletal tissue. Wnt7b stimulates SP7 within bone marrow cells stromal cells. It activates transcription factors that promote osteoblastogenesis. This is essential for bone wellness and bone health.

Researchers can use the SP7 gene to study the role of osteogenesis in human bone. The SP7 genes is a genetic marker that monitors osteoblasts and other tissues. SP7 was used in animal models to monitor bone tissue growth. The results of these experiments show that SP7 is very relevant to bone metabolism.

RIOX1 is negatively controlled by Sp7

Recent research suggests that the Sp7 genes may be involved in osteogenesis. Sp7 is an essential master regulator of bone development as an osteoprogenitor. It plays a pivotal role in both embryonic development and homeostatic bone maintenance. SP7's full structure remains unknown. Further research is needed to determine if this gene interacts or how it affects osteogenesis.

Bone formation is a complicated process. Osx is essential for the final commitment of the osteoblast lineage. Recent molecular studies have positioned Osx as a master regulator of osteoblast differentiation. Osx regulation is still not fully understood and future research is required to discover their role. Sp7 serves as an interim marker that allows for the study of bone formation.