Transcription factor Sp6 Antibodies

Transcription factor Sp6 (SP6)

Promotes cell proliferation. .

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Gene Information

Human
Gene Name:	SP6
Uniprot:	Q3SY56
Entrez:	80320

Family

Belongs to:
Sp1 C2H2-type zinc-finger protein family

Alternative Names

Epfn; EPIPROFIN; KLF14MGC119663; Krueppel-like factor 14; Kruppel-like factor 14; MGC119662; MGC119664; MGC119665; Sp6 transcription factor; transcription factor Sp6

Molecular Weight

Mass (kDA):
39.84 kDA

Genomic Context

Human
Location:	17q21.32
Sequence:	17; NC_000017.11 (47844908..47876312, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus.

Diseases

• Pain
• Neoplasms
• Melanoma
• Uveal Melanoma
• Uveal Neoplasms
• Malignant Neoplasms
• Salmonella Infections
• Dysmenorrhea
• Hepatitis
• Immunologic Deficiency Syndromes
• Primary Dysmenorrhea
• Hiv Infections
• Leukemia

• Infective Disorder
• Carcinoma
• Chimera Disorder
• Vesicular Stomatitis
• Stomatitis
• Malignant Paraganglionic Neoplasm
• Neoplasm Metastasis

Pathways

• Translation
• Localization
• Transport
• Reverse Transcription
• Secretion
• Glycosylation
• Cell Proliferation
• Proteolysis
• Cell Growth
• Dna Replication
• Pathogenesis
• Menstruation
• Cell Death

• Rna Processing
• Cell Adhesion
• Cell Cycle
• Amelogenesis
• Translational Initiation
• Reflex
• Ameloblast Differentiation

PTMs

• Cleavage
• Phosphorylation
• Glycosylation
• Methylation

• Biotinylation
• Oxidation
• Acetylation
• Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP6

Boster Bio - Best Uses Of The SP6 Marker

What is SP6? The protein is part of a group of transcription factors with three classical zinc finger DNA-binding domains. The zinc atom of the protein has two histidines and two cysteines that are tied tetrahedrally. This gene-encoding protein interacts with the GC-rich sequences, as well as related GT and CACCC box boxes. Boster's SP6 antibody has been validated against previously identified positive and negative samples to ensure precise detection and results.

Boster Bio-Engineeting Company

The SP6 gene encodes a transcription factor that binds DNA. It has three traditional zinc finger DNA binding domains and an atom of zinc that is tetrahedrally connected by two histidines and two cysteines. It binds to GC rich sequences as well as related GT or CACCC boxes. All antibodies that Boster uses are validated with positive and negative samples.

Anti-SP6 Marker

The Anti-SP6 antibody in Boster BIO has been tested against bovine, mouse and human cells. The antibody was used in a variety of applications, such as flow cytometry and immunocytochemistry. Promega supplied a TnT SP6-coupled extract of reticulocytes, for in vitro translations. The nuclear and cytoplasmic extracts were separated on a 12% SDS/PAGE.

Transcription is a key factor

The SP6 marker is a particular epitope of the ribosomal protein S6. It is found on the surface of many cells and is used for determining the identity of certain cancerous cells. This marker is also used for the detection of a variety of human illnesses such as cancer. This marker can also be useful in scientific forensics. Its high affinity and specificity allows it to be used in immunohistochemistry, Western Blotting, and ELISA.

The SP6 gene can be found in many tissues, including spleen, skin and the skin. In addition to that, the SP6 marker is utilized in many molecular diagnostic tests. The SP6 promoter area is conserved in human blood. It is essential for detection of various genetic diseases such as cancer. This makes SP6 the ideal gene for identifying the presence of a tumor cell.