Transcription factor Sp1 Antibodies

Transcription factor Sp1 (SP1)

Binds with higher affinity to GC-rich themes and regulates the expression of a large number of genes involved in many different processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation).

May have a role in regulating the cellular response to DNA damage. Implicated in chromatin remodeling.

Gene Information

Human
Gene Name:	SP1
Uniprot:	P08047
Entrez:	6667

Family

Belongs to:
Sp1 C2H2-type zinc-finger protein family

Alternative Names

Sp1 transcription factor; specificity protein 1; transcription factor Sp1; TSFP1

Molecular Weight

Mass (kDA):
80.693 kDA

Genomic Context

Human
Location:	12q13.13
Sequence:	12; NC_000012.12 (53380176..53416446)

Tissue Specificity

Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.

Subcellular Localizations

Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Malignant Neoplasm Of Breast
• Liver Carcinoma
• Mammary Neoplasms
• Hiv Infections
• Immunologic Deficiency Syndromes
• Cell Transformation, Neoplastic
• Neoplasm Metastasis
• Leukemia
• Malignant Paraganglionic Neoplasm

• Tumor Angiogenesis
• Adenocarcinoma
• Neuroblastoma
• Inflammation
• Cell Invasion
• Nervousness
• Tissue Adhesions

Interacting Proteins

• AATF
• CDKN2A
• DLX4
• E2F1
• ELF1

• EPAS1
• ESR1
• HCFC1
• HDAC1
• HIF1A

• KLF10
• MYC
• NCK1
• Nfya
• PHC2

• POGZ
• POU2F1
• RUNX1T1
• SF3A1
• SMAD4

• SREBF2
• STAT3
• TBX21
• TP53
• ZBTB2

Pathways

• Methylation
• Cell Cycle
• Translation
• Cell Proliferation
• Cell Growth
• Localization
• Pathogenesis
• Angiogenesis
• Secretion
• Dna Methylation
• Cell Differentiation
• Cell Death
• Transport

• Rna Interference
• Cell Cycle Arrest
• Dna Replication
• Cell Adhesion
• Histone Acetylation
• Senescence
• S Phase

PTMs

• Phosphorylation
• Methylation
• Acetylation
• Cleavage
• Dephosphorylation
• Glycosylation
• Demethylation
• Oxidation
• Deacetylation
• Reduction

• Ubiquitination
• Sumoylation
• Phosphorothioation
• Ribosylation
• Deamination
• Biotinylation
• Carboxylation
• Myristoylation
• Nitrosylation
• Hydroxylation

Research Areas

• Cancer
• Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP1

Best Uses of the SP1 Marker From Boster Bio

You might have heard about the SP1 marker as a molecular biologist, and are interested in its application. But what are the most effective uses of this specific marker? Continue reading to find out more. Boster Bio provides comprehensive technical resources, such as blogs as well as information on diseases and web-based digital tools. In addition, the company offers quality lysis buffers for excellent results and reduce cross-linking intensity.

Boster Bio's Anti-Macrosialin Antibody CD68

The Anti-Macrosialin CD68 antibody from Boster Bio has been tested for use in IF IHC and IHCF methods. This antibody is highly specific and binds to specific lectins that are specific to organs and tissues. It may be involved in homing macrophage subsets to specific sites , and allows them to crawl over the cells and surfaces that contain selectins. The rapid recirculation of the cytosol could be a factor in its ability to bind selectin-bearing substrates , and also help regulate the functions of these cells.

This antibody recognizes CD68 which is a 110 kD glycoprotein found on macrophages as well as monocytes. The CD68 antigen is part of the sialomucin group that also includes LAMPs. It is found most often on monocytes and dendritic cell, making it a useful marker for myeloid cells. Its expression has been identified in other myeloid cells, including a subset of hematopoietic stem cells, I3/I' T cells I' T cells, fibroblasts, and endotocytes.

The role of CD68 isn't fully understood, but it has been utilized as an immunohistochemical marker for the treatment of inflammation and cancer. A poor prognosis is linked to CD68+ macrophages that are tumor-associated. A review of all studies found that CD68+ macrophages associated with tumors were not associated with survival. It also blocks the entry of parasites into Kupffer cells.