Sox6 Antibodies

Transcription factor SOX-6 (Sox6)

Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'.

Plays a vital role in a number of developmental processes, such as neurogenesis and skeleton formation. .

Gene Information

Mouse
Gene Name:	Sox6
Uniprot:	P40645
Entrez:	20679

Family

Belongs to:
No superfamily

Alternative Names

HSSOX6; SOX6; SOXD; SRY (sex determining region Y)-box 6; SRY-box containing gene 6; transcription factor SOX-6

Molecular Weight

Mass (kDA):
91.803 kDA

Genomic Context

Mouse
Location:	7 F1|7 61.29 cM
Sequence:	7;

Tissue Specificity

Highly expressed in testis.

Diseases

• Hypertrophy
• Fracture
• Nervousness
• Malignant Neoplasms
• Neoplasms
• Glioma
• Osteoporosis
• Crest Syndrome
• Carcinoma
• Degenerative Polyarthritis
• Hypoxia
• Dysplasia

• Hemoglobinopathies
• Obesity
• Anemia
• Brain Neoplasms
• Anemia, Sickle Cell
• Congenital Abnormality
• Insulin Resistance

Pathways

• Chondrocyte Differentiation
• Cell Differentiation
• Ossification
• Cell Proliferation
• Neurogenesis
• Sex Determination
• Chondrocyte Proliferation
• Endochondral Ossification
• Cell Growth
• Regeneration
• Cartilage Development
• Insulin Secretion
• Secretion

• Cell Adhesion
• Osteoblast Differentiation
• Chondrocyte Hypertrophy
• Limb Development
• Cell Maturation
• Regulation Of Chondrocyte Differentiation
• Pathogenesis

PTMs

• Phosphorylation

• Acetylation

• Sumoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sox6

Boster Bio - The Best Uses Of The SOX6 Marker

You've heard of Steven Boster and his Anti Transcription factor SOX-6 (SOX6 Antibody) but do you know much about SOX6? You're not alone. You're not the only scientist who uses this software. This information is relevant to all scientists. Read on to learn more about how it works and what benefits of using it.

Anti-Transcription factor SOX-6 SoX6 Antibody

Boster Bio Anti-Transcription factor Sox-6 (SOX6) antibody recognizes a specific sequence in the human genome. This antibody is designed to be used in the study of immunohistochemistry. It recognizes SOX6 and its target gene miR-129-5p. There are many copies of SOX6 in the human genome. These copies are also present in all tissues.

The Sox family of genes consists of genes that have DNA-binding HMG domains. EsSoxB2-1 is a novel Sox gene. It is a new Sox homolog derived from mitten crab. This gene encodes an RNA protein that is 95% identical to Tribolium castaneum SOX21b. However it is not a lot of similarity to SOX21b beyond the HMG box. SoxB2-1 is an untranslated gene , and has a gonad-specific expression. Multi-intron structure is one of the characteristics of the insect Sox21 gene.

Benefits of using the SOX6 Marker

The SOX6 marker is a chimeric, Recombination protein with its primary function in promoting terminal differentiation in erythroid cell lines. It also induces apoptosis in non-erythroid cell types and promiscuous ones. This marker has numerous benefits. It can be used to study gene function and to aid in the research of cancer. It is an extremely sensitive and specific gene marker for analyzing the effect of SOX6 on cell growth.

In addition to its role in recombination, SOX6 acts as a functional enhancer in a variety of cell kinds. It binds to certain DNA sequences and regulates specific chondrocyte-specific genes. This marker can be used to provide targeted therapy for cancer patients at a lower risk. The SOX6 marker can be used in both hematologic and skeletal muscle cells.

This gene is frequently altered in many types cancers. In many types of cancer, SOX6 expression is downregulated. Downregulated SOX6 expression is associated with a poor prognosis. Conversely, SOX6 overexpression mitigates the malignant manifestation. Certain cancers have higher levels of SOX6 than other tumors. Its role in the immune system is undetermined. Although SOX6 is a tumor suppressor, its overexpression can result in leukemia and cell death.

SOX6 is highly responsive to DNA-binding DNA. The SOX9 gene is very similar, but it has two distinct regions. These are the proximal and far-distal regions. The proximal portion contains 10-50 kb while the far-distant area is between 50 and 250 kb. These regions are associated with specific patterns. These motifs can help researchers identify the genes that are in active transcription.

Global ChIP-seq analysis gives new insights into the chondrogenic actions of the SOX trio. Although the method has its limitations, it provides valuable insight. The genome-wide analysis of the SOX trio has identified new targets. They include Chst11 and Wwp2. Fgfr3 (and Sox9) are two other targets that were recently discovered by SOX6.

SOX6 is one of the genes that has a broad anti-proliferative function and an underlying dual mechanism. Low levels of SOX6 were associated with poor prognosis among 173 patients suffering from AML. Its level of expression may assist researchers to pinpoint specific genes that influence cancer growth. If SOX6 is decreased cancer cells could be more resistant to treatment.