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Sortilin Antibodies
AND SORT1 ELISA kits, Sortilin Proteins
Many biological assays use antibodies to detect Sortilin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sortilin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sortilin antibodies...
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SORT1 Infographic by Boster Bio
All SORT1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M01666
100 µl
Cat # M01666
100 µl
SORT1 Overview
Facts about Sortilin.
Sortilin (SORT1)
Acts as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR).
Also required for protein transport from the Golgi apparatus to the endosomes. Also acts as a receptor for neurotensin.
Gene Information
| Human | |
|---|---|
| Gene Name: | SORT1 |
| Uniprot: | Q99523 |
| Entrez: | 6272 |
Family
| Belongs to: |
|---|
| VPS10-related sortilin family |
Alternative Names
100 kDa NT receptor; Glycoprotein 95; Gp95; Gp95LDLCQ6; Neurotensin receptor 3; NT3NTR3; Ntr3; SORT1; sortilin 1; Sortilin
Molecular Weight
Mass (kDA):
92.068 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.3|1p21.3-p13.1 |
| Sequence: | 1; NC_000001.11 (109309565..109397940, complement) |
Tissue Specificity
Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver.
Subcellular Localizations
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane; Single-pass type I membrane protein. Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membr
Diseases
- Coronary Artery Disease
- Infarction
- Myocardial Infarction
- Cardiovascular Diseases
- Atherosclerosis
- Dementia
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Heart Diseases
- Frontotemporal Lobar Degeneration
- Dyslipidemias
- Coronary Heart Disease
- Dysequilibrium Syndrome
Interacting Proteins
- GGA1
- GRN
- LRPAP1
- NGF
- NTRK1
- NTRK3
Pathways
- Secretion
- Endocytosis
- Receptor-mediated Endocytosis
- Transport
- Cell Proliferation
- Phagosome Maturation
- Osteoblast Differentiation
- Brain Development
- Aging
- Stem Cell Maintenance
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SORT1
bosterbio.com/bosterbio-gene-info-cards/SORT1
References
PMID: 9013611 by Petersen C.M., et al. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.
PMID: 9756851 by Mazella J., et al. The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein- coupled receptor.