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- Table of Contents
, No Gclids
SOS1 Antibodies
AND SOS1 ELISA kits, SOS1 Proteins
Many biological assays use antibodies to detect SOS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SOS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SOS1 antibodies...
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SOS1 Infographic by Boster Bio
All SOS1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00837
100 μl
Cat # M00837
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00837-1
100 μg/vial
Cat # A00837-1
100 μg/vial
SOS1 Overview
Facts about Son of sevenless homolog 1.
Son of sevenless homolog 1 (SOS1)
Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579).
Probably by promoting Ras activation, modulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331).Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | SOS1 |
| Uniprot: | Q07889 |
| Entrez: | 6654 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
GF1GGF1; GINGF; guanine nucleotide exchange factor; HGFhereditary, 1; NS4; son of sevenless homolog 1 (Drosophila); son of sevenless homolog 1; SOS-1
Molecular Weight
Mass (kDA):
152.464 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p22.1 |
| Sequence: | 2; NC_000002.12 (38981549..39124959, complement) |
Tissue Specificity
Expressed in gingival tissues.
Diseases
- Noonan Syndrome
- Malignant Neoplasms
- Neoplasms
- Dwarfism
- Congenital Heart Defects
- Heart Diseases
- Hypertrophy
- Cell Transformation, Neoplastic
- Fibromatosis
- Cardio-facio-cutaneous Syndrome
- Hypertrophic Cardiomyopathy
- Cardiomyopathies
Interacting Proteins
- COPS3
- CRK
- CRKL
- GRB2
- HCK
- HRAS
- NCK1
- NEB
- PACSIN3
- PIK3R1
Pathways
- Cell Proliferation
- Pathogenesis
- Transport
- Ion Homeostasis
- Cell Cycle
- Localization
- Cell Growth
- Cell Death
- Cell Migration
- Cell Activation
- Endocytosis
- Mapk Cascade
- Cell Motility
PTMs
- Phosphorylation
- Myristoylation
- Farnesylation
- Prenylation
Research Areas
- Breast Cancer
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOS1
bosterbio.com/bosterbio-gene-info-cards/SOS1
References
PMID: 8493579 by Chardin P., et al. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
PMID: 7664271 by Pandey P., et al. Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.