SOD3 Antibodies

Extracellular superoxide dismutase [Cu-Zn] (SOD3)

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. .

Gene Information

Human
Gene Name:	SOD3
Uniprot:	P08294
Entrez:	6649

Family

Belongs to:
Cu-Zn superoxide dismutase family

Alternative Names

ECSOD; EC-SOD; EC-SODEC 1.15.1.1; extracellular superoxide dismutase [Cu-Zn]; MGC20077; SOD3; superoxide dismutase 3, extracellular

Molecular Weight

Mass (kDA):
25.851 kDA

Genomic Context

Human
Location:	4p15.2
Sequence:	4; NC_000004.12 (24795478..24800845)

Tissue Specificity

Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

Subcellular Localizations

Secreted, extracellular space. 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.

Diseases

• Inflammation
• Lung Diseases
• Hypertensive Disease
• Malignant Neoplasms
• Chronic Obstructive Airway Disease
• Ischemia
• Lung Diseases, Obstructive
• Fibrosis
• Lung Injury
• Cardiovascular Diseases
• Neoplasms
• Atherosclerosis

• Diabetes Mellitus
• Myocardial Ischemia
• Pneumonia
• Heart Diseases
• Pulmonary Fibrosis
• Hypoxia

Interacting Proteins

• KCNIP3
• SGTA

Pathways

• Pathogenesis
• Aging
• Localization
• Secretion
• Inflammatory Response
• Cell Proliferation
• Transport
• Virulence
• Immune Response
• Vasoconstriction
• Vasodilation
• Lung Development
• Cell Death

• Excretion
• Protein Oxidation
• Cell Migration
• Secretory Pathway
• Neutrophil Chemotaxis
• Germination
• Proteolysis

PTMs

• Phosphorylation
• Oxidation
• Reduction
• Cleavage
• Glycosylation

• Acetylation
• Carboxylation
• Nitration
• Amidation
• Methylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOD3

Best Uses of the SOD3 Marker

The SOD3 Marker has several benefits. Scientists can employ it in various applications and in particular samples. It is safe for human consumption and has many potential uses. Keep reading for more information. These are just a few of the advantages. These benefits are available to scientists around the world. But why should scientists make use of it? What are the most effective uses of it? What are the most effective uses?

SOD is based on plants

A plant-based SOD3 marker could be a promising health supplement. It is unlikely to cause any adverse side effects. SOD is a natural ingredient of a variety of plants that are under-utilized. It can be used as a source of soluble dietary fibres as well as SOD. It could also be a source of diet fibers that serve as encapsulation agents. Here are some examples.

The study also looked at the effect of water deficiency on the activity of SOD. In the sensitive varieties, SOD activity was highest at the beginning of drought, but decreased towards the close of flowering. In winter squash plants, SOD activity was highest in genotypes with purple leaves. The SOD activity was lower in the sensitive varieties of the plant, while the savoy-type genotypes had bumpy leaves.

Diabetes sufferers have significantly higher plasma levels of SOD3 than those with no diabetes. These studies also demonstrated positive correlations between CKD or diabetes, as well as both. The levels of SOD3 were found to be higher in those suffering from CKD and diabetes than in healthy individuals. It was interesting to observe that there was no relationship between urinary SOD3 and the presence of VEGF or ANG. It's too early to determine if plant-based SOD3 can be used as a measure to assess nephropathy and disease severity.

HMDM cells were stimulated with LPS and supernatants taken at the time indicated. Immunoprecipitation/Western blotting was performed to confirm the presence of SOD3 in supernatant. The transcriptional activity was assessed through RT-qPCR following LPS stimulation. As it is expected, LPS stimulates secretion of SOD3.

LPS also increased cell surface-associated HMDM cells SOD3. The results demonstrated that LPS produced more SOD3 in HMDM cells while BAPTA/AM stimulated intracellular vesicles containing SOD3-containing LPS. This suggests that LPS increases the number of lipid rafts with SOD3 in them. LPS also stimulates HMDMs in release of SOD3 which can be analyzed in the supernatants or lysates.

Exogenous SOD administration against various illnesses

SOD is an important antioxidant in the body and is a crucial part of the defense against oxidative stress. Numerous studies have revealed the physiological and therapeutic benefits of SOD. The antioxidant enzyme helps prevent cancerous cell mutations through its anti-inflammatory effects. SOD levels decrease with the advancing years. Exogenous SOD supplements can improve your body's health.

In comparison to other antioxidants SOD does not cause adverse reactions. The anti-inflammatory properties of SOD is due to its ability to block neutrophil activity and a short half-life of circulating that is 6 min. Exogenous SOD administration can help protect against hyperoxic lung injuries. Cu/Zn SOD significantly decreased pulmonary capillary protein leakage , and also reduced inflammation, oxidative stress, and inflammation.

Diabetes physiopathology includes the polyols pathway , protein kinase C activation as along with hexosamine flow rates and the advanced Glycation-End-Products pathway. While all of these pathways contribute to oxidative stress, the liver is particularly vulnerable to this kind of damage. Exogenous SOD administration can protect the liver from such damage.

The polymersome process can improve the delivery of SOD to the tissues. This vesicle has favorable biodistribution, pharmacokinetics and solubility. Its properties allow for the exploration of numerous NPs as carriers for SOD. SOD has been carried out using polymersomes as vehicles which include liposomes, hollow silica nanospheres. They may contain SOD but the enzyme that is encapsulated within them is highly susceptible to degrading.

Transfection of the human aortic aortic cell with an Adenovirus-mediated virus has been proven to reduce TNF-a-induced expressions of AP-1 and NFKB. In addition, AdSOD pretransfected HAECs reduce neutrophil adhesion TNF-a-treated HAECs.

It is not known whether SOD-containing supplements possess an anti-inflammatory effect. However, it may boost the antioxidant defense of the lung. Exogenous SOD treatment has also been shown to boost FEV and RI in human beings. While the causes of the SOD-related increase in GPx-1 are not understood but it has been proven that exogenous SOD administration is linked to an improvement in the respiratory system. The upregulation of GPx-1 has been proven to reduce the inflammatory reaction in the lungs.

Human consumption is safe and healthy.

Foodborne diseases can be caused by viruses, bacteria and parasites aswell as chemicals. Foods can be contaminated by contaminants from a variety of sources, including industrial production, agricultural practices and even military operations. They can vary from acute poisoning to long-term illnesses. A lot of the most frequent foodborne illnesses are contagious and can even cause death. It is important to know what is safe and what is not. Here are some methods you can determine if food is safe for consumption by humans.

The European Food Safety Authority has published the first scientific opinion evaluating insect-derived foods, concluding that mealworm is safe for humans to consume. The opinion was included in the latest batch of EFSA's scientific opinions on new food applications. The opinion was drafted by Ermolaos Ververis, a scientist at the agency. Since insects are complex organisms, understanding their microbiology is essential. When developing new food products, it's important to consider safety precautions including mealworms.

Foodborne diseases are a significant public health problem. Foodborne diseases are a significant public concern in both developed and developing countries. Food security is a top priority for developing countries. Food Safety and Human Health offers a framework to manage these risks and ensure the safety of food supply. By promoting food safety an improved food system will be created and help protect the health of humans. This report presents the results of the latest research and the best practices for ensuring food security.

This definition has been endorsed by regulatory bodies like the American Dietetic Association and the European Commission. Companies that make money from the use of regulated substances must produce data that shows the substance is safe for human consumption. These companies must also pay for any new research that proves a product's safety. The EFSA rigorously evaluates all data submitted and carefully evaluates study designs. The FDA will also assess products made with bioengineered ingredients.

Potential for animal health enhancement

The SOD3 marker is an intriguing genetic marker for improving the health of animals. Its encapsulation in soluble dietary fibres offers a sustainable solution to agricultural therapies. This study will investigate the application of soluble diet fibers as a carrier for SOD in plants. Through its encapsulation in food fibers, the SOD3 gene may be able increase the production and availability of antioxidants in livestock.

SOD is an important antioxidant enzyme that plays a role in physiological defense strategies in plants and animals. While plant-derived SOD might not be readily available, encapsulated melon SOD has been demonstrated in mammalian wellness to improve the health of animals. However, SOD made from melon may not be a viable commercial product due to gluten intolerance. It has also been demonstrated that it enhances the immune system of animals. SOD in wheat Gliadin Encapsulated melon Extracts has positive effects on mammalian health. However, these dietary supplements have a low bioavailability.

In the future these technologies will extend to other species and be used to create new traits by genetic improvement. These technologies will also harness the effects of heterosis as well as epigenetic mechanisms to adapt genomes to specific contexts. Different genomes will be compatible with designer pre/probiotics or metabolites. This will ultimately improve productivity and well-being for animals. The animal genome community is uniquely placed to enhance this research and help to develop convergent agricultural health practices.

Since the SOD3 gene has been identified as a possible gene for improving the health of animals Researchers will now begin to investigate its potential to improve the production of livestock as well as improve the health of animals. Before, scientists have utilized genomic methods to improve the knowledge base of biological sciences for various animal species that are used in agriculture. There have been 7,558 peer-reviewed publications that have reported research on genomics of the 13 species included in the Blueprint. This is 44% of all publications on animal production published between 1949 and the present.