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- Table of Contents
Facts about Suppressor of cytokine signaling 2.
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. .
Human | |
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Gene Name: | SOCS2 |
Uniprot: | O14508 |
Entrez: | 8835 |
Belongs to: |
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No superfamily |
CIS2; CIS2CIS-2; Cish2; Cytokine-inducible SH2 protein 2; SOCS2; SOCS-2; SOCS-2STAT-induced STAT inhibitor 2; SSI2; SSI-2STAT induced STAT inhibitor-2; SSI2STAT-induced STAT inhibitor-2; STATI2; STATI2suppressor of cytokine signaling-2; suppressor of cytokine signaling 2
Mass (kDA):
22.172 kDA
Human | |
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Location: | 12q22 |
Sequence: | 12; NC_000012.12 (93569849..93626236) |
High expression in heart, placenta, lung, kidney and prostate.
PMID: 9266833 by Minamoto S., et al. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.
PMID: 9344848 by Masuhara M., et al. Cloning and characterization of novel CIS family genes.