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Sorting nexin-5 Antibodies
AND SNX5 ELISA kits, Sorting nexin-5 Proteins
Many biological assays use antibodies to detect Sorting nexin-5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sorting nexin-5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sorting nexin-5 antibodies...
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SNX5 Infographic by Boster Bio
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SNX5 Overview
Facts about Sorting nexin-5.
Sorting nexin-5 (SNX5)
Involved in several stages of intracellular trafficking. Acts in part as part of the retromer membrane-deforming SNX-BAR subcomplex.
The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes into the trans-Golgi network (TGN) and is included in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane to a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable).
Gene Information
| Human | |
|---|---|
| Gene Name: | SNX5 |
| Uniprot: | Q9Y5X3 |
| Entrez: | 27131 |
Family
| Belongs to: |
|---|
| sorting nexin family |
Alternative Names
FLJ10931; sorting nexin 5; sorting nexin-5
Molecular Weight
Mass (kDA):
46.816 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p11.23 |
| Sequence: | 20; NC_000020.11 (17941600..17968794, complement) |
Subcellular Localizations
Endosome. Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation.
Diseases
- Malignant Neoplasms
- Fanconi Anemia
- Anemia
- Carcinoma
- Instabilities, Chromosomal
- Cell Transformation, Neoplastic
- Malignant Squamous Cell Neoplasm
- Anxiety Disorders
- Malignant Paraganglionic Neoplasm
- Stomatitis
- Pancytopenia
- Physiological Stress
Interacting Proteins
- APPBP2
- SNX1
Pathways
- Transport
- Macropinocytosis
- Endocytosis
- Localization
- Notch Signaling Pathway
- Regeneration
- Intracellular Transport
- Blood Vessel Development
PTMs
- Acetylation
Research Areas
- Core ESC-Like Genes
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNX5
bosterbio.com/bosterbio-gene-info-cards/SNX5
References
PMID: 11485546 by Teasdale R.D., et al. A large family of endosome-localized proteins related to sorting nexin 1.
PMID: 15561769 by Merino-Trigo A., et al. Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation.