Sorting nexin-2 Antibodies

AND SNX2 ELISA kits, Sorting nexin-2 Proteins

Many biological assays use antibodies to detect Sorting nexin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sorting nexin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sorting nexin-2 antibodies...

We validate the specificity of these antibodies to Sorting nexin-2 by testing them on tissues known to express SNX2 positively and negatively. Browse below to find the SNX2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SNX2 Infographic by Boster Bio

All SNX2 Products

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SNX2 (NM_003100) Human Recombinant Protein

$1062
Cat # PROTO60749
20 µg

SNX2 (NM_003100) Human Over-expression Lysate

Human

$628
Cat # LS006643
100 µg

SNX2 Overview

Facts about Sorting nexin-2.

SNX2 3D structure. Source: alphafold

Sorting nexin-2 (SNX2)

Involved in many stages of intracellular trafficking. Acts in part as part of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778).

The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes into the trans-Golgi network (TGN) and is included in endosome-to-plasma membrane transport for freight protein recycling. The SNX-BAR subcomplex works to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable).

Gene Information

Human
Gene Name:	SNX2
Uniprot:	O60749
Entrez:	6643

Family

Belongs to:

sorting nexin family

Alternative Names

MGC5204; sorting nexin 2; sorting nexin-2; Transformation-related gene 9 protein; TRG-9

Molecular Weight

Mass (kDA):
58.471 kDA

Genomic Context


Human

Location:	5q23.2
Sequence:	5; NC_000005.10 (122774996..122834543)

Subcellular Localizations

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901).

Diseases

Leukemia
Acute Myelomonocytic Leukemia
Cell Transformation, Neoplastic
Charcot-marie-tooth Disease
Malignant Paraganglionic Neoplasm
Cholera
Acute Lymphocytic Leukemia
Fetal Growth Retardation
Epilepsy
Brain Pathology

Virilism
Peripheral Neuropathy
Tetraploidy
Precursor B-cell Lymphoblastic Leukemia-lymphoma

Interacting Proteins

FNBP1
SNX1
SNX32
SNX6

Pathways

Transport
Localization
Vesicle Localization
Endocytosis
Lipid Phosphorylation
Intracellular Transport
Transcytosis
Embryo Development
Cell Division

Oocyte Development
Reverse Transcription
Lipid Binding
Rna Interference

PTMs

Phosphorylation

Cleavage

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNX2

References

PMID: 9819414 by Haft C.R., et al. Identification of a family of sorting nexin molecules and characterization of their association with receptors.

PMID: 11102511 by Renfrew Haft C., et al. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.