Beta-2-syntrophin Antibodies

AND SNTB2 ELISA kits, Beta-2-syntrophin Proteins

Many biological assays use antibodies to detect Beta-2-syntrophin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-2-syntrophin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-2-syntrophin antibodies...

We validate the specificity of these antibodies to Beta-2-syntrophin by testing them on tissues known to express SNTB2 positively and negatively. Browse below to find the SNTB2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SNTB2 Infographic by Boster Bio

All SNTB2 Products

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Syntrophin (SNTB2) (NM_006750) Human Recombinant Protein

$1062
Cat # PROTQ13425
20 µg

Syntrophin (SNTB2) (NM_006750) Human Over-expression Lysate

Human

$628
Cat # LS006645
100 µg

SNTB2 Overview

Facts about Beta-2-syntrophin.

SNTB2 3D structure. Source: alphafold

Beta-2-syntrophin (SNTB2)

Adapter protein that binds to and likely organizes the subcellular localization of a variety of membrane proteins. May connect various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

May play a role in the regulation of secretory granules via its interaction with PTPRN. .

Gene Information

Human
Gene Name:	SNTB2
Uniprot:	Q13425
Entrez:	6645

Family

Belongs to:

syntrophin family

Alternative Names

D16S2531E; EST25263; SNT2B2dystrophin-associated protein A1, 59kD, basic component 2; SNT3beta-2-syntrophin; SNTLsyntrophin-3; syntrophin, beta 2 (dystrophin-associated protein A1, 59kD, basic component 2); syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2); Syntrophin-3,59 kDa dystrophin-associated protein A1 basic component 2; Syntrophin-like

Molecular Weight

Mass (kDA):
57.95 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (69187147..69309052)

Tissue Specificity

Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed.

Subcellular Localizations

Membrane. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Cell junction. Cytoplasm, cytoskeleton. Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity). In insulinoma cell line, it is enriched in secretory granules.

Diseases

Haploinsufficiency
Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Cytogenetic Abnormality
Neoplasm Invasiveness
Loss Of Chromosome 16q
Invasive Breast Carcinoma

Ductal Breast Carcinoma
Carcinoma
Carcinogenesis

Interacting Proteins

ADRA1D
CASK
DMD

Pathways

Telomere Binding

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SNTB2

References

PMID: 8576247 by Ahn A.H., et al. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

PMID: 11043403 by Ort T., et al. The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells.