Vacuolar-sorting protein SNF8 (SNF8)

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The ESCRT-II complicated is probably involved in the recruitment of the ESCRT-III complicated.

The ESCRT-II complex may also play a role in transcription regulation by engaging in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization.