SMN1 Antibodies

AND SMN1 ELISA kits, SMN1 Proteins

Many biological assays use antibodies to detect SMN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMN1 antibodies...

We validate the specificity of these antibodies to SMN1 by testing them on tissues known to express SMN1 positively and negatively. Browse below to find the SMN1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMN1 Infographic by Boster Bio

All SMN1 Products

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Product

Figures

Specificity

Applications

Price

Anti-SMN1/2 Antibody Picoband®

4 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB9398
100 μg/vial

Anti-SMN1/2 Antibody Picoband® (monoclonal, 2B10)

Human, Mouse, Rat

IHC, ICC, WB

$370
Cat # M03420-1
100 μg/vial

Anti-SMN1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M03420-2
100 μl/vial

SMN1 (NM_022874) Human Over-expression Lysate

Human

$628
Cat # LS006606
100 µg

SMN1 Overview

Facts about Survival motor neuron protein.

SMN1 3D structure. Source: alphafold

Survival motor neuron protein (SMN1)

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs.

Most spliceosomal snRNPs have a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complicated by the chaperone CLNS1A that controls the assembly of the core snRNP.

Gene Information

Human
Gene Name:	SMN1
Uniprot:	Q16637
Entrez:	6606

Family

Belongs to:

SMN family

Alternative Names

Gemin-1; Kugelberg-Welander disease); SMNC; survival motor neuron protein; survival of motor neuron 1, telomeric

Molecular Weight

Mass (kDA):
31.849 kDA

Genomic Context


Human

Location:	5q13.2
Sequence:	5; NC_000005.10 (70924941..70953015)

Tissue Specificity

Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).

Subcellular Localizations

Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with actin and at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules (PubMed:14715275). Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies (PubMed:11283611). Colocalizes with FMR1 in cytoplasmic granules in the soma and neurite cell processes (PubMed:18093976