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SMC3 Antibodies
AND SMC3 ELISA kits, SMC3 Proteins
Many biological assays use antibodies to detect SMC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMC3 antibodies...
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SMC3 Infographic by Boster Bio
All SMC3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01930
100 μl
Cat # M01930
100 μl
Human, Mouse, Rat
IHC, WB
$370
Cat # M01930-1
100 μg/vial
Cat # M01930-1
100 μg/vial
SMC3 Overview
Facts about Structural maintenance of chromosomes protein 3.
Structural maintenance of chromosomes protein 3 (SMC3)
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped.
In anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMC3 |
| Uniprot: | Q9UQE7 |
| Entrez: | 9126 |
Family
| Belongs to: |
|---|
| SMC family |
Alternative Names
Bamacan; BAMSMC protein 3; Basement membrane-associated chondroitin proteoglycan; BMH; chondroitin sulfate proteoglycan 6 (bamacan); Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide; CSPG6structural maintenance of chromosomes protein 3; hCAP; HCAPbamacan; SMC-3; SMC3L1CDLS3; structural maintenance of chromosomes 3
Molecular Weight
Mass (kDA):
141.542 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q25.2 |
| Sequence: | 10; NC_000010.11 (110567695..110606048) |
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity).
Diseases
- Cornelia De Lange Syndrome
- Malignant Neoplasms
- Genomic Instability
- Neoplasms
- Aneuploidy
- Congenital Abnormality
- Carcinoma
- Developmental Disabilities
- Hereditary Diseases
- Cell Transformation, Neoplastic
- Developmental Delay (disorder)
- Ataxia
Interacting Proteins
- MCMBP
- PDS5A
- PDS5B
- RAD21
- SMC1A
- STAG1
- STAG2
Pathways
- Sister Chromatid Cohesion
- Anaphase
- Mitosis
- Chromosome Segregation
- S Phase
- Meiosis
- Prophase
- Metaphase
- Dna Replication
- Cell Cycle
- Localization
- Dna Repair
- Pachytene
PTMs
- Acetylation
- Phosphorylation
- Cleavage
- Deacetylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Chromatin Research
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMC3
bosterbio.com/bosterbio-gene-info-cards/SMC3
References
PMID: 9506951 by Shimizu K., et al. Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide.
PMID: 18614053 by Zhang J., et al. Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.