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SMC1A Antibodies
AND SMC1A ELISA kits, SMC1A Proteins
Many biological assays use antibodies to detect SMC1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMC1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMC1A antibodies...
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SMC1A Infographic by Boster Bio
All SMC1A Products
Product
Figures
Specificity
Applications
Price
Anti-SMC1 SMC1A Monoclonal Antibody
2 Citations
Human, Mouse, Pig, Rat
Flow Cytometry, IHC, WB
$399
Cat # A02148-2
100μl
Cat # A02148-2
100μl
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M02148
100 μl
Cat # M02148
100 μl
Human, Mouse
ELISA
$480
Cat # EKC1531
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1531
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2120
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2120
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2510
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2510
1 kit, containing two 96-well plates and all necessary reagents
SMC1A Overview
Facts about Structural maintenance of chromosomes protein 1A.
Structural maintenance of chromosomes protein 1A (SMC1A)
Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication.
The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. In anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMC1A |
| Uniprot: | Q14683 |
| Entrez: | 8243 |
Family
| Belongs to: |
|---|
| SMC family |
Alternative Names
CDLS2; DXS423ESMC1 structural maintenance of chromosomes 1-like 1 (yeast); KIAA0178DKFZp686L19178; SB1.8; SB1.8MGC138332; segregation of mitotic chromosomes 1; SMC protein 1A; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 1; SMC1; SMC1A; SMC-1A; SMC-1-alpha; SMC1L1; SMC1SMC1alpha; Smcb; structural maintenance of chromosomes 1A; structural maintenance of chromosomes protein 1A
Molecular Weight
Mass (kDA):
143.233 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xp11.22 |
| Sequence: | X; NC_000023.11 (53374149..53422728, complement) |
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere, kinetochore. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. T
Diseases
- Cornelia De Lange Syndrome
- Congenital Abnormality
- Developmental Disabilities
- Growth Retardation
- Developmental Delay (disorder)
- Limb Defect
- Congenital Anomaly Of Face
- Microcephaly
- Hereditary Diseases
- Genomic Instability
- Impaired Cognition
Interacting Proteins
- CDCA5
- MCM7
- RAD21
- RAE1
- SGO1
- SMC3
- STAG2
Pathways
- Sister Chromatid Cohesion
- Cell Cycle
- Regulation Of Gene Expression
- Chromosome Segregation
- Aging
- Meiosis
- Rumination
- Anaphase
- Reflex
- Response To Oxidative Stress
- Cell Division
- Reverse Transcription
- Translation
PTMs
- Acetylation
- Phosphorylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Checkpoint signaling
- Chromatin Research
- DNA Double Strand Break Repair
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMC1A
bosterbio.com/bosterbio-gene-info-cards/SMC1A
References
PMID: 7757074 by Rocques P.J., et al. The human SB1.8 gene (DXS423E) encodes a putative chromosome segregation protein conserved in lower eukaryotes and prokaryotes.
PMID: 11877377 by Yazdi P.T., et al. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S- phase checkpoint.
2 Publications of Boster SMC1A Antibodies & ELISA Kits
- PubMed ID: 10.3760/cma.j.issn.0366-6999.2011.06.020, Imaging of atherosclerotic aorta of rabbit model by detection of plaque inflamma...
- PubMed ID: 10.1016/j.atherosclerosis.2009.04.014, Chymase activity is closely related with plaque vulnerability in a hamster model...
*More publications can be found for each product on its corresponding product page