SLCO1C1 Antibodies

AND SLCO1C1 ELISA kits, SLCO1C1 Proteins

Many biological assays use antibodies to detect SLCO1C1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLCO1C1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLCO1C1 antibodies...

We validate the specificity of these antibodies to SLCO1C1 by testing them on tissues known to express SLCO1C1 positively and negatively. Browse below to find the SLCO1C1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLCO1C1 Infographic by Boster Bio

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SLCO1C1 (NM_017435) Human Over-expression Lysate

Human

$628
Cat # LS053919
100 µg

SLCO1C1 Overview

Facts about Solute carrier organic anion transporter family member 1C1.

SLCO1C1 3D structure. Source: alphafold

Solute carrier organic anion transporter family member 1C1 (SLCO1C1)

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency.

May play a signifiant part in regulating T4 flux into and out of the brain (By similarity). .

Gene Information

Human
Gene Name:	SLCO1C1
Uniprot:	Q9NYB5
Entrez:	53919

Family

Belongs to:

organo anion transporter (TC 2.A.60) family

Alternative Names

OATP1; OATP14; OATP14Thyroxine transporter; OATP1C1; OATP1C1Solute carrier family 21 member 14; OATPF; OATPFOAT-RP-5; OATP-FOrganic anion-transporting polypeptide 14; OATPRP5; OATRP5; Organic anion transporter F; Organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; SLC21A14; SLC21A14OATP-14; SLCO1C1; solute carrier family 21 (organic anion transporter), member 14; solute carrier organic anion transporter family member 1C1; solute carrier organic anion transporter family, member 1C1

Molecular Weight

Mass (kDA):
78.696 kDA

Genomic Context


Human

Location:	12p12.2
Sequence:	12; NC_000012.12 (20681800..20753386)

Tissue Specificity

Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity).

Diseases

Hypothyroidism
Cholestasis
Nervousness
Injury To Liver
Inflammation
Drug-induced Liver Injury
Neoplasms
Hepatitis
Liver Diseases
Adenoma
Malnutrition
Glioma

Hepatitis Cholestatic
Trauma, Nervous System
Allan-herndon-dudley Syndrome (ahds)
Paroxysmal Nocturnal Dyspnea
Pituitary Diseases
Primary Hypothyroidism
Thyroid Hormone Resistance Syndrome

Pathways

Transport
Hormone Transport
Thyroid Hormone Transport
Brain Development
Excretion
Anion Transport
Organic Anion Transport
Localization
Neuroprotection
Regeneration

Drug Transport
Liver Regeneration
Pathogenesis
Secretion

PTMs

Carboxylation

Deiodination

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLCO1C1

References

PMID: 12351693 by Pizzagalli F., et al. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.

PMID: 18687783 by Roberts L.M., et al. Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.