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- Table of Contents
Facts about Sodium-dependent neutral amino acid transporter B(0)AT1.
In a Xenopus oocyte assay, the substrate preference is the following: Leu > Gln > Phe = Ala > His = Trp >> Glu = Arg. .
Mouse | |
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Gene Name: | Slc6a19 |
Uniprot: | Q9D687 |
Entrez: | 74338 |
Belongs to: |
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sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family |
B0AT1; FLJ20680; FLJ34635; HND; sodium-dependent amino acid transporter system B0; sodium-dependent neutral amino acid transporter B(0)AT1; solute carrier family 6 (neurotransmitter transporter), member 19; solute carrier family 6 (neutral amino acid transporter), member 19; Solute carrier family 6 member 19; System B(0) neutral amino acid transporter AT1; system B0 neutral amino acid transporter
Mass (kDA):
71.367 kDA
Mouse | |
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Location: | 13|13 C1 |
Sequence: | 13; |
Predominantly expressed in kidney and small intestine. Expression not observed in other organs, such as lung, skeletal muscle, brain, liver and pancreas. In kidney, expression is localized in the renal cortex but not in the medulla. Substantial amounts of expression in the proximal tubules. The distal nephron segments and the glomeruli are consistently negative. In the small intestine, expression is exclusively localized in villus enterocytes. High resolution of the hybridization-positive villi reveals a gradient of expression with the highest levels in apical cells. Not detected in crypt cells or in any other cell types of the small intestine.
PMID: 15044460 by Broeer A., et al. Molecular cloning of mouse amino acid transport system B(0), a neutral amino acid transporter related to Hartnup disorder.
PMID: 15804236 by Boehmer C., et al. Characterization of mouse amino acid transporter B(0)AT1 (Slc6a19).