SLC5A12 Antibodies

AND SLC5A12 ELISA kits, SLC5A12 Proteins

Many biological assays use antibodies to detect SLC5A12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC5A12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC5A12 antibodies...

We validate the specificity of these antibodies to SLC5A12 by testing them on tissues known to express SLC5A12 positively and negatively. Browse below to find the SLC5A12 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC5A12 Infographic by Boster Bio

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SLC5A12 Overview

Facts about Sodium-coupled monocarboxylate transporter 2.

SLC5A12 3D structure. Source: alphafold

Sodium-coupled monocarboxylate transporter 2 (SLC5A12)

Acts as an electroneutral and low-affinity sodium (Na(+))-reliant sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate.

May be responsible for the first step of reabsorption of monocarboxylates in the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport from the retina (By similarity).

Gene Information

Human
Gene Name:	SLC5A12
Uniprot:	Q1EHB4
Entrez:	159963

Family

Belongs to:

sodium:solute symporter (SSF) (TC 2.A.21) family

Alternative Names

Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; MGC52019; SMCT2DKFZp564G223; sodium-coupled monocarboxylate transporter 2; sodium-iodide related cotransporter; solute carrier family 5 (sodium/glucose cotransporter), member 12; Solute carrier family 5 member 12

Molecular Weight

Mass (kDA):
67.647 kDA

Genomic Context


Human

Location:	11p14.2
Sequence:	11; NC_000011.10 (26667020..26723356, complement)

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity).

Diseases

Familial Renal Hypouricemia
Hypouricaemia
Disease Of Adrenal Medulla
Cardiovascular Diseases
Hyperuricemia
Malignant Neoplasms
Hypertrophy
Neoplasms

Pituitary Diseases
Left Ventricular Hypertrophy

Pathways

Transport
Localization
Fermentation
Excretion
Urate Transport
Glucose Homeostasis
Regulation Of Glucose Homeostasis
Cellular Localization

Drug Transport
Renal Absorption
Nicotinate Transport

PTMs

Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC5A12

References

PMID: 17692818 by Gopal E., et al. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney.