SLC4A5 Antibodies

AND SLC4A5 ELISA kits, SLC4A5 Proteins

Many biological assays use antibodies to detect SLC4A5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC4A5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC4A5 antibodies...

We validate the specificity of these antibodies to SLC4A5 by testing them on tissues known to express SLC4A5 positively and negatively. Browse below to find the SLC4A5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC4A5 Infographic by Boster Bio

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Anti-SLC4A5 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A07878
100ul

SLC4A5 Overview

Facts about Electrogenic sodium bicarbonate cotransporter 4.

SLC4A5 3D structure. Source: alphafold

Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5)

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of cells in which it's expressed.

May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.

Gene Information

Human
Gene Name:	SLC4A5
Uniprot:	Q9BY07
Entrez:	57835

Family

Belongs to:

anion exchanger (TC 2.A.31) family

Alternative Names

electrogenic sodium bicarbonate cotransporter 4; MGC129662; NBC4Solute carrier family 4 member 5; NBCe2; solute carrier family 4, sodium bicarbonate cotransporter, member 5

Molecular Weight

Mass (kDA):
126.255 kDA

Genomic Context


Human

Location:	2p13.1
Sequence:	2; NC_000002.12 (74216242..74343416, complement)

Tissue Specificity

Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.

Diseases

Hypertensive Disease
Disease Of Adrenal Medulla
Acidosis
Obesity
Hypoaldosteronism
Metabolic Alkalosis
Metabolic Acidosis
Retinal Detachment
Renal Tubular Acidosis
Hypoaldosteronism, Hyporeninemic
Diabetes Mellitus

Peripheral Arterial Diseases
Innate Immune Response
Nervousness
Arteriopathic Disease
Alkalosis
Visual Impairment

Pathways

Transport
Localization
Innate Immune Response
Immune Response
Excretion
Glomerular Filtration

Secretion

PTMs

Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC4A5

References

PMID: 10978526 by Pushkin A., et al. Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family.

PMID: 11087115 by Pushkin A., et al. Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization.