SLC4A4 Antibodies

AND SLC4A4 ELISA kits, SLC4A4 Proteins

Many biological assays use antibodies to detect SLC4A4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC4A4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC4A4 antibodies...

We validate the specificity of these antibodies to SLC4A4 by testing them on tissues known to express SLC4A4 positively and negatively. Browse below to find the SLC4A4 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC4A4 Infographic by Boster Bio

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SLC4A4 Overview

Facts about Electrogenic sodium bicarbonate cotransporter 1.

SLC4A4 3D structure. Source: alphafold

Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)

Electrogenic sodium/bicarbonate cotransporter using a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux in the basolateral membrane of cells and regulate intracellular pH.

Gene Information

Human
Gene Name:	SLC4A4
Uniprot:	Q9Y6R1
Entrez:	8671

Family

Belongs to:

anion exchanger (TC 2.A.31) family

Alternative Names

electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC1; KNBC; kNBC1; Na(+)/HCO3(-) cotransporter; NBC; NBC1DKFZp781H1314; NBC2; NBCE1; pNBC; SLC4A5; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney;sodium bicarbonate cotransporter, pancreas); Sodium bicarbonate cotransporter; Solute carrier family 4 member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5

Molecular Weight

Mass (kDA):
121.461 kDA

Genomic Context


Human

Location:	4q13.3
Sequence:	4; NC_000004.12 (71062646..71572087)

Tissue Specificity

Isoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.

Subcellular Localizations

Basolateral cell membrane; Multi-pass membrane protein.

Diseases

Acidosis
Renal Tubular Acidosis
Proximal Renal Tubular Acidosis
Metabolic Acidosis
Cystic Fibrosis
Fibrosis
Glaucoma
Disease Of Adrenal Medulla
Neoplasms
Hypertensive Disease
Dwarfism
Alkalosis

Malignant Neoplasms
Band-shaped Keratopathy
Renal Tubular Acidosis, Type I
Salivary Gland Diseases
Hypoxia
Cataract

Pathways

Transport
Secretion
Localization
Excretion
Bicarbonate Transport
Ion Transport
Regulation Of Intracellular Ph
Pathogenesis
Membrane Depolarization
Endocytosis
Amelogenesis
Wound Healing
Anion Transport

Fluid Transport
Cell Migration
Reverse Transcription
Translation
Cell Cycle
Exocytosis
Insulin Secretion

PTMs

Phosphorylation
Biotinylation
Glycosylation

Dephosphorylation
Carboxylation
Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC4A4

References

PMID: 9235899 by Burnham C.E., et al. Cloning and functional expression of a human kidney Na+:HCO3- cotransporter.

PMID: 9651366 by Abuladze N., et al. Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter.