SLC47A1 Antibodies

AND SLC47A1 ELISA kits, SLC47A1 Proteins

Many biological assays use antibodies to detect SLC47A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC47A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC47A1 antibodies...

We validate the specificity of these antibodies to SLC47A1 by testing them on tissues known to express SLC47A1 positively and negatively. Browse below to find the SLC47A1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC47A1 Infographic by Boster Bio

All SLC47A1 Products

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Anti-SLC47A1 Antibody

Human, Rat

$405
Cat # A04529
100ul

Anti-MATE-1/SLC47A1 Antibody Picoband®

Human, Mouse, Rat

ELISA, WB

$370
Cat # A04529-2
100 μg/vial

SLC47A1 Overview

Facts about Multidrug and toxin extrusion protein 1.

SLC47A1 3D structure. Source: alphafold

Multidrug and toxin extrusion protein 1 (SLC47A1)

Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir as well as the zwitterionic cephalosporin, cephalexin and cephradin. Appears to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent).

Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs throughout the brush border membranes.

Gene Information

Human
Gene Name:	SLC47A1
Uniprot:	Q96FL8
Entrez:	55244

Family

Belongs to:

multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family

Alternative Names

hMATE-1; MATE-1; MATE1FLJ10847multidrug and toxin extrusion 1; MGC64822; multidrug and toxin extrusion protein 1; Solute carrier family 47 member 1; solute carrier family 47, member 1

Molecular Weight

Mass (kDA):
61.922 kDA

Genomic Context


Human

Location:	17p11.2
Sequence:	17; NC_000017.11 (19533854..19579034)

Tissue Specificity

Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Predominantly localized at the plasma membrane but also found in intracellular organelles.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Kidney Diseases
Malignant Neoplasms
Cholangiocarcinoma
Persistent Fetal Circulation Syndrome
Vaccinia
Reperfusion Injury
Malignant Neoplasm Of Breast
Kidney Failure, Chronic
Acute Kidney Injury
Biliary Obstruction

Polycystic Ovary Syndrome
Injury To Kidney
Cholestasis
Neoplasms
Diabetes Mellitus, Insulin-dependent
Chronic Kidney Disease

Pathways

Transport
Secretion
Excretion
Glomerular Filtration
Renal Tubular Secretion
Organic Cation Transport
Response To Metformin
Cation Transport
Localization

Gluconeogenesis
Drug Transport
Pathogenesis
Glucose Transport

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC47A1

References

PMID: 16330770 by Otsuka M., et al. A human transporter protein that mediates the final excretion step for toxic organic cations.

PMID: 16641166 by Hiasa M., et al. Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations.