Zinc transporter 5 Antibodies

AND SLC30A5 ELISA kits, Zinc transporter 5 Proteins

Many biological assays use antibodies to detect Zinc transporter 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc transporter 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc transporter 5 antibodies...

We validate the specificity of these antibodies to Zinc transporter 5 by testing them on tissues known to express SLC30A5 positively and negatively. Browse below to find the SLC30A5 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC30A5 Infographic by Boster Bio

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SLC30A5 Overview

Facts about Zinc transporter 5.

SLC30A5 3D structure. Source: alphafold

Zinc transporter 5 (SLC30A5)

Functions as a zinc transporter. Might be a transporter of zinc into beta cells in order to form insulin crystals.

Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs).

Gene Information

Human
Gene Name:	SLC30A5
Uniprot:	Q8TAD4
Entrez:	64924

Family

Belongs to:

cation diffusion facilitator (CDF) transporter (TC 2.A.4) family

Alternative Names

FLJ12756; MGC5499; solute carrier family 30 (zinc transporter), member 5; zinc transporter 5; zinc transporter ZTL1; ZnT-5FLJ12496; ZNT5Solute carrier family 30 member 5; ZNTL1hZTL1; ZTL1ZnT-like transporter 1

Molecular Weight

Mass (kDA):
84.047 kDA

Genomic Context


Human

Location:	5q13.1-q13.2
Sequence:	5; NC_000005.10 (69093993..69131069)

Tissue Specificity

Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin- containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.

Subcellular Localizations

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.

Diseases

Zinc Deficiency Disorder
Diabetes Mellitus
Alzheimer's Disease
Endoplasmic Reticulum Stress
Cardiac Death
Deafness Congenital
Inflammatory Bowel Diseases
Enterovirus Infections
Immediate Hypersensitivity
Intestinal Diseases
Immunologic Deficiency Syndromes
Pancreatitis

Delayed Hypersensitivity
Malignant Neoplasms
Autoimmune Lymphoproliferative Syndrome
5,10-methylenetetrahydrofolate Reductase Deficiency
Dental Plaque
Allergy
Deficiency Diseases

Pathways

Transport
Localization
Secretory Pathway
Dna Methylation
Methylation
Cell Activation
Anaphylaxis
Hypersensitivity
Cardiac Conduction
Mast Cell Activation
Dna Replication

Cytokine Production
Cellular Localization
Mrna Stabilization
Cell Growth
Glycolysis
Secretion

PTMs

Methylation

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC30A5

References

PMID: 11904301 by Kambe T., et al. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.

PMID: 11937503 by Cragg R.A., et al. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.