Equilibrative nucleoside transporter 4 (SLC29A4)

Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations like monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters.

May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Doesn't appear to transport nucleoside and nucleoside analogs like uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine.