Solute carrier family 26 member 6 (SLC26A6)

Apical membrane anion-exchanger with broad epithelial distribution that plays a role as a component of the pH buffering system for preserving acid-base homeostasis. Acts as a versatile DIDS-sensitive organic and inorganic anion transporter which mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions such as sulfate and oxalate.

Function in multiple exchange modes involving pairs of these anions, including chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride- formate exchange. Apical membrane chloride-bicarbonate exchanger which mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and leads to intracellular pH regulation in the duodenal upper villous epithelium through proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway.