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SLC22A2 Antibodies
AND SLC22A2 ELISA kits, SLC22A2 Proteins
Many biological assays use antibodies to detect SLC22A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC22A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC22A2 antibodies...
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SLC22A2 Infographic by Boster Bio
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SLC22A2 Overview
Facts about Solute carrier family 22 member 2.
Solute carrier family 22 member 2 (SLC22A2)
Mediates tubular uptake of organic chemicals from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin.
Cisplatin may develop a nephrotoxic action. Transfer of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX.
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC22A2 |
| Uniprot: | O15244 |
| Entrez: | 6582 |
Family
| Belongs to: |
|---|
| major facilitator (TC 2.A.1) superfamily |
Alternative Names
hOCT2; MGC32628; OCT2; OCT2Organic cation transporter 2; SLC22A2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22 member 2
Molecular Weight
Mass (kDA):
62.581 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q25.3 |
| Sequence: | 6; NC_000006.12 (160216755..160258821, complement) |
Tissue Specificity
Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma.
Subcellular Localizations
Membrane; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Kidney Diseases
- Diabetes Mellitus
- Lymphoma
- Kidney Failure
- Acute Kidney Injury
- Injury To Kidney
- Diabetes Mellitus, Non-insulin-dependent
- Hodgkin Disease
- Hypertensive Disease
- Disease Of Adrenal Medulla
Pathways
- Transport
- Secretion
- Excretion
- Cation Transport
- Organic Cation Transport
- Localization
- Glomerular Filtration
- Renal Tubular Secretion
- Methylation
- Dna Methylation
- Antiport
- Drug Transport
- Choline Transport
PTMs
- Methylation
- Biotinylation
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC22A2
bosterbio.com/bosterbio-gene-info-cards/SLC22A2
References
PMID: 9260930 by Gorboulev V., et al. Cloning and characterization of two human polyspecific organic cation transporters.
PMID: 12089365 by Urakami Y., et al. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.