This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Solute carrier family 22 member 4.
Also transports organic cations such as tetraethylammonium (TEA) with no involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.
Human | |
---|---|
Gene Name: | SLC22A4 |
Uniprot: | Q9H015 |
Entrez: | 6583 |
Belongs to: |
---|
major facilitator (TC 2.A.1) superfamily |
Ergothioneine transporter; ET transporter; ETT; MGC34546; MGC40524; OCTN1; OCTN1integral membrane transport protein; Organic cation/carnitine transporter 1; SLC22A4; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; solute carrier family 22 member 4; UT2H
Mass (kDA):
62.155 kDA
Human | |
---|---|
Location: | 5q31.1 |
Sequence: | 5; NC_000005.10 (132294384..132344199) |
Widely expressed. Highly expressed in whole blood, bone marrow, trachea and fetal liver. Weakly expressed in kidney, skeletal muscle, prostate, lung, pancreas, placenta, heart, uterus, spleen and spinal cord. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells. Predominantly expressed in CD14 cells in peripheral blood mononuclear cells.
Membrane; Multi-pass membrane protein.
PMID: 9426230 by Tamai I., et al. Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1.
PMID: 15795384 by Gruendemann D., et al. Discovery of the ergothioneine transporter.