SLC18A1 Antibodies

Chromaffin granule amine transporter (SLC18A1)

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. .

Gene Information

Human
Gene Name:	SLC18A1
Uniprot:	P54219
Entrez:	6570

Family

Belongs to:
major facilitator superfamily

Alternative Names

CGAT; SLC18A1; solute carrier family 18 (vesicular monoamine), member 1; VAT1; VMAT1

Molecular Weight

Mass (kDA):
56.257 kDA

Genomic Context

Human
Location:	8p21.3
Sequence:	8; NC_000008.11 (20144855..20183206, complement)

Tissue Specificity

Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).

Subcellular Localizations

[Isoform 1]: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

• Neoplasms
• Disease Of Adrenal Medulla
• Nervousness
• Schizophrenia
• Carcinoid Tumor
• Bipolar Disorder
• Pheochromocytoma
• Pancreatic Neoplasm
• Crest Syndrome
• Adenocarcinoma
• Mental Disorders
• Depressive Disorder
• Gastrointestinal Neoplasms

• Neuroblastoma
• Neuroendocrine Tumors
• Neoplasm Metastasis
• Hypoxia
• Ileal Neoplasms
• Mastocytosis
• Adrenal Gland Neoplasms

Pathways

• Transport
• Secretion
• Exocytosis
• Localization
• Dopamine Transport
• Drug Resistance
• Serotonin Secretion
• Pathogenesis
• Secretory Pathway
• Cell Migration
• Glycosylation
• Monoamine Transport
• Amine Transport

• Dopamine Uptake
• Serotonin Transport
• Methylation
• Norepinephrine Transport
• Antiport
• Cell Differentiation
• Social Behavior

PTMs

• Phosphorylation
• Reduction
• Cleavage

• Glycosylation
• Amidation
• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC18A1

Boster Bio: Best Uses Of The SLC18A1 Marker

This Boster Bio will provide you with a brief history of Steven Boster, His current research, and upcoming projects. You will also find out about His books. This bio is an invaluable resource for anyone who is interested in advancing our knowledge about the SLC18A1 marker. You'll be able to use this genetic marker in your own research after reading this Boster bio: Best Uses of The SLC18A1Marker.

History of Steven Boster

Steven Boster, a lifelong researcher and historian, compiled many public records that provide information about his past as well as present. You can find Steve Boster's current home address and previous addresses, as well as cell phone numbers and emails, as well as known relatives. To find out more about Steve Boster's life, you can search his public records by state and age. Here are some highlights about Steve Boster.

Don "Steve" Boster grew up in Joliet on July 22, 1924. He died from COVID-19, June 26, 2022. Boster was born to James and Evelyn Meier. He served in the U.S. Army for a time, and was a member of Concordia Hall in Staunton, VA. Boster is survived by his mother Frances, his sisters Kimberly and Tammy, and his son Jonathan and grandson Cory.

His current research

His recent discovery of the SLC18A1 gene marked the beginning of his research on the disease. This gene codes the vesicular monamine transporter (VMAT1) protein, which carries neurochemicals throughout your body. This protein is often misfunctioned, which can lead to a variety mental disorders. Several amino acid variants in VMAT1 cause various disorders and mutations at this site are a major part of his current research.