SLC18A1 Antibodies

AND SLC18A1 ELISA kits, SLC18A1 Proteins

Many biological assays use antibodies to detect SLC18A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC18A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC18A1 antibodies...

We validate the specificity of these antibodies to SLC18A1 by testing them on tissues known to express SLC18A1 positively and negatively. Browse below to find the SLC18A1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC18A1 Infographic by Boster Bio

All SLC18A1 Products

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Specificity

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Price

Anti-VMAT1/SLC18A1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A07692-1
100 μg/vial

Anti-VMAT1 SLC18A1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A07692-2
100ul

SLC18A1 Overview

Facts about Chromaffin granule amine transporter.

SLC18A1 3D structure. Source: alphafold

Chromaffin granule amine transporter (SLC18A1)

Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. .

Gene Information

Human
Gene Name:	SLC18A1
Uniprot:	P54219
Entrez:	6570

Family

Belongs to:

major facilitator superfamily

Alternative Names

CGAT; SLC18A1; solute carrier family 18 (vesicular monoamine), member 1; VAT1; VMAT1

Molecular Weight

Mass (kDA):
56.257 kDA

Genomic Context


Human

Location:	8p21.3
Sequence:	8; NC_000008.11 (20144855..20183206, complement)

Tissue Specificity

Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).

Subcellular Localizations

[Isoform 1]: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Neoplasms
Disease Of Adrenal Medulla
Nervousness
Schizophrenia
Carcinoid Tumor
Bipolar Disorder
Pheochromocytoma
Pancreatic Neoplasm
Crest Syndrome
Adenocarcinoma
Mental Disorders
Depressive Disorder
Gastrointestinal Neoplasms

Neuroblastoma
Neuroendocrine Tumors
Neoplasm Metastasis
Hypoxia
Ileal Neoplasms
Mastocytosis
Adrenal Gland Neoplasms

Pathways

Transport
Secretion
Exocytosis
Localization
Dopamine Transport
Drug Resistance
Serotonin Secretion
Pathogenesis
Secretory Pathway
Cell Migration
Glycosylation
Monoamine Transport
Amine Transport

Dopamine Uptake
Serotonin Transport
Methylation
Norepinephrine Transport
Antiport
Cell Differentiation
Social Behavior

PTMs

Phosphorylation
Reduction
Cleavage

Glycosylation
Amidation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC18A1

References

PMID: 8643547 by Erickson J.D., et al. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter.

PMID: 16326835 by Essand M., et al. Identification and characterization of a novel splicing variant of vesicular monoamine transporter 1.