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- Table of Contents
Facts about Solute carrier family 12 member 6.
May contribute to cell volume homeostasis in single cells. .
Human | |
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Gene Name: | SLC12A6 |
Uniprot: | Q9UHW9 |
Entrez: | 9990 |
Belongs to: |
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SLC12A transporter family |
ACCPN; agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome); DKFZp434D2135; EC 1.2.4.1; EC 6.1.1.3; Electroneutral potassium-chloride cotransporter 3; KCC3; KCC3A; KCC3B; KCC3potassium chloride cotransporter 3; K-Cl cotransporter 3; potassium chloride cotransporter KCC3a-S3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; SLC12A6; solute carrier family 12 (potassium/chloride transporters), member 6; solute carrier family 12 member 6
Mass (kDA):
127.617 kDA
Human | |
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Location: | 15q14 |
Sequence: | 15; NC_000015.10 (34229784..34338057, complement) |
Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level).
Basolateral cell membrane; Multi-pass membrane protein.
PMID: 10600773 by Race J.E., et al. Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter.
PMID: 10187864 by Hiki K., et al. Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter.