Slc12a5 Antibodies

AND Slc12a5 ELISA kits, Slc12a5 Proteins

Many biological assays use antibodies to detect Slc12a5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Slc12a5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Slc12a5 antibodies...

We validate the specificity of these antibodies to Slc12a5 by testing them on tissues known to express Slc12a5 positively and negatively. Browse below to find the Slc12a5 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Slc12a5 Infographic by Boster Bio

All Slc12a5 Products

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Product

Figures

Specificity

Applications

Price

Anti-KCC2/SLC12A5 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A04629-1
100 μg/vial

KCC2 (SLC12A5) (NM_020708) Human Over-expression Lysate

Human

$960
Cat # LS057468
100 µg

Slc12a5 Overview

Facts about Solute carrier family 12 member 5.

Solute carrier family 12 member 5 (Slc12a5)

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As important extruder of intracellular chloride, it establishes the adrenal Cl(-) levels required for bile influx after binding of GABA-A and glycine to their receptors, together with subsequent hyperpolarization and neuronal inhibition.

Involved in the regulation of dendritic spine formation and maturation. .

Gene Information

Mouse
Gene Name:	Slc12a5
Uniprot:	Q91V14
Entrez:	57138

Family

Belongs to:

SLC12A transporter family

Alternative Names

Electroneutral potassium-chloride cotransporter 2; hKCC2; KCC2; KCC2K-Cl cotransporter 2; KIAA1176erythroid K-Cl cotransporter 2; Neuronal K-Cl cotransporter; SLC12A5; solute carrier family 12 (potassium/chloride transporter), member 5; solute carrier family 12 member 5

Molecular Weight

Mass (kDA):
126.271 kDA

Genomic Context


Mouse

Location:	2\|2 H3
Sequence:	2;

Tissue Specificity

Isoform 2 expressed in brainstem and spinal cord, isoform 1 expressed in brainstem, spinal cord and olfactory bulb of E17 embryos. Isoforms 1 and 2 expressed in all parts of the brain and spinal cord in postnatal day 14 mice.

Diseases

Nervousness
Neuroblastoma
Schizophrenia
Depressive Disorder
Spinal Cord Injuries
Mood Disorders
Diabetic Nephropathy
Gitelman Syndrome
Hepatitis C, Chronic
Columnar Cell Change Of The Breast
Teratocarcinoma
Lung Diseases
Carcinogenesis

Edema
Patient Dependence On
Bartter Disease
Neoplasms
Bipolar Disorder
Muscle Spasticity
Hepatitis

Pathways

Transport
Brain Development
Cell Motility
Ion Transport
Localization
Reflex

Secretion

PTMs

Carboxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Slc12a5

References

PMID: 11471062 by Ehringer M.A., et al. High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PMID: 10077537 by Haapa S., et al. An efficient DNA sequencing strategy based on bacteriophage Mu in vitro DNA transposition reaction.