SLC12A3 Antibodies

AND SLC12A3 ELISA kits, SLC12A3 Proteins

Many biological assays use antibodies to detect SLC12A3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC12A3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC12A3 antibodies...

We validate the specificity of these antibodies to SLC12A3 by testing them on tissues known to express SLC12A3 positively and negatively. Browse below to find the SLC12A3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC12A3 Infographic by Boster Bio

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SLC12A3 Overview

Facts about Solute carrier family 12 member 3.

SLC12A3 3D structure. Source: alphafold

Solute carrier family 12 member 3 (SLC12A3)

Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145).

Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2.

Gene Information

Human
Gene Name:	SLC12A3
Uniprot:	P55017
Entrez:	6559

Family

Belongs to:

SLC12A transporter family

Alternative Names

FLJ96318; Na-Cl symporter; NCC; NCCT; SLC12A3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12 member 3; thiazide-sensitive Na-Cl cotransporter; Thiazide-sensitive sodium-chloride cotransporter; TSC; TSCNaCl electroneutral thiazide-sensitive cotransporter

Molecular Weight

Mass (kDA):
113.139 kDA

Genomic Context


Human

Location:	16q13
Sequence:	16; NC_000016.10 (56865207..56915850)

Tissue Specificity

Predominantly expressed in kidney (PubMed:8812482). Not detected in normal aorta, but abundantly expressed in fatty streaks and advanced atherosclerotic lesions (at protein level) (PubMed:26099046).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Gitelman Syndrome
Alkalosis
Hypertensive Disease
Metabolic Alkalosis
Bartter Disease
Tuberous Sclerosis
Kidney Diseases
Essential Hypertension
Hyperaldosteronism
Weakness
Pseudohypoaldosteronism
Diabetes Mellitus

Hypercalciuria
Hypotension Adverse Event
Renal Tubular Disorder
Diabetic Nephropathy
Magnesium Deficiency
Nephrocalcinosis

Pathways

Transport
Excretion
Localization
Pathogenesis
Diuresis
Ion Transport
Natriuresis
Secretion
Glomerular Filtration
Glycosylation
Endocytosis
Aging
Renal Sodium Excretion

Water Transport
Regulation Of Blood Pressure
Chloride Transport
Cellular Localization
Protein Processing
Iodide Transport
Gene Silencing

PTMs

Phosphorylation
Glycosylation

Ubiquitination
Biotinylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC12A3

References

PMID: 8528245 by Simon D.B., et al. Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter.

PMID: 8812482 by Mastroianni N., et al. Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3).