SLC10A2 Antibodies

AND SLC10A2 ELISA kits, SLC10A2 Proteins

Many biological assays use antibodies to detect SLC10A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC10A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC10A2 antibodies...

We validate the specificity of these antibodies to SLC10A2 by testing them on tissues known to express SLC10A2 positively and negatively. Browse below to find the SLC10A2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC10A2 Infographic by Boster Bio

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SLC10A2 Overview

Facts about Ileal sodium/bile acid cotransporter.

SLC10A2 3D structure. Source: alphafold

Ileal sodium/bile acid cotransporter (SLC10A2)

Plays a crucial role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a vital role in cholesterol metabolism.

Gene Information

Human
Gene Name:	SLC10A2
Uniprot:	Q12908
Entrez:	6555

Family

Belongs to:

bile acid:sodium symporter (BASS) (TC 2.A.28) family

Alternative Names

Apical sodium-dependent bile acid transporter; ASBT; IBAT; ileal apical sodium-dependent bile acid transporter; Ileal Na(+)/bile acid cotransporter; ileal sodium/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; ISBT; Na(+)-dependent ileal bile acid transporter; NTCP2; NTCP2PBAM; PBAM; SLC10A2; Sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Solute carrier family 10 member 2

Molecular Weight

Mass (kDA):
37.714 kDA

Genomic Context


Human

Location:	13q33.1
Sequence:	13; NC_000013.11 (103043998..103066417, complement)

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Malabsorption Syndrome
Malignant Neoplasms
Diarrhea
Cholestasis
Hypercholesterolemia
Cholecystolithiasis
Polyps
Colorectal Neoplasms
Cholelithiasis
Colorectal Cancer
Adenoma
Hyperlipoproteinemia Type Iv

Neoplasms
Headache
Dysequilibrium Syndrome
Steatorrhea
Diabetes Mellitus
Crohn Disease

Pathways

Transport
Localization
Excretion
Intestinal Absorption
Cellular Localization
Secretion
Gallstone Formation
Cholesterol Homeostasis
Anion Transport
Insulin Secretion

Organic Anion Transport
Regeneration
Protein Folding
Liver Regeneration
Intestinal Cholesterol Absorption

PTMs

Ubiquitination
Phosphorylation

Carboxylation
Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC10A2

References

PMID: 7592981 by Wong M.H., et al. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity.

PMID: 9109432 by Oelkers P., et al. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).