SKAP2 Antibodies

Src kinase-associated phosphoprotein 2 (SKAP2)

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation.

May play a role in src signaling pathway. .

Gene Information

Human
Gene Name:	SKAP2
Uniprot:	O75563
Entrez:	8935

Family

Belongs to:
SKAP family

Alternative Names

Fyn-associated phosphoprotein SKAP55 homologue; PRAP; RA70Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SAPSSKAP55 homolog; SCAP2MGC33304; SKAP55RSKAP-55HOM; SKAP-HOMMGC10411; src family associated phosphoprotein 2; Src family-associated phosphoprotein 2; src kinase associated phosphoprotein 2; src kinase-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; src kinase-associated phosphoprotein of 55-related protein; Src-associated adapter protein with PH and SH3 domains; src-associated adaptor protein

Molecular Weight

Mass (kDA):
41.217 kDA

Genomic Context

Human
Location:	7p15.2
Sequence:	7; NC_000007.14 (26654772..26864623, complement)

Tissue Specificity

Ubiquitously expressed. Present in platelets (at protein level).

Subcellular Localizations

Cytoplasm.

Diseases

• Adenocarcinoma
• Pancreatic Ductal Adenocarcinoma
• Tissue Adhesions
• Diabetes Mellitus
• Carcinogenesis
• Cataract
• Malignant Neoplasms
• Carcinoma, Pancreatic Ductal
• Pancreatic Neoplasm

• Diabetes Mellitus, Insulin-dependent
• Malignant Neoplasm Of Pancreas
• Ductal Breast Carcinoma

Interacting Proteins

• PTPN22

Pathways

• Rna Interference

PTMs

• Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SKAP2

Boster Bio: Best Uses Of The SKAP2 Marker

Boster produces antibodies that have many benefits. Boster antibodies can be validated across multiple platforms using known positive or negative samples. Boster's antibodies are highly specific and affinity. Boster also offers product credits for first-time reviewers. These antibodies can be used by scientists around the globe.

Boster validates all antibodies on WB and IHC, ICC, Immunofluorescence or Immunofluorescence

It is important to validate an antibody before it is used in a study. WB isn't a perfect science, but it can still be an important tool to validate an antibody. Most antibodies used for antibody studies are not validated, or have minimal validation. This can lead a lot to incorrect data. As a result, Boster validates all of its antibodies on WB, IHC, ICC, and Immunofluorescence.

WB, and IHC are both main methods for immunostaging the cells. ICC uses intact cells, while immunofluorescence uses fluorescent markers to identify specific proteins and their distribution. ICC/IHC can be performed on tissue sections as well as individual cells. Researchers can use these methods to determine the distribution of proteins and other biological compounds, including DNA, RNA, or RNA.

WB is essential for determining the specificity and quality of an antibody. This screen must be performed before any IHC/ICC experiment. Often, research communities misunderstand this step, but it is not. All Boster antibodies are validated on WB before they are used in other applications. WB and ICC data can be combined to create a more specific antibody.

Boster has a monoclonal anti-CTLA4 antibody that can be used for IHC, ICC and immunofluorescence. This monoclonal anti-CTLA4 antibody reacts with Human and is supplied as 0.1 mg in liquid form. CTLA4 is an inhibitory receptor. Its affinity for ligands is much stronger than the cognate stimulatory coreceptor, CD28. It also exhibits lower levels of expression than CD28.

Boster offers high-affinity prim antibodies

Steven Boster invented his first antibody product in late 1990's. It earned him the nickname "he Who Converts Science in the Lavatory". He went on to develop hundreds of primary antibodies and IHC kits, as well as a variety of commercial products for researchers. PicoKine(tm) was also established in the late 1990s. It uses proprietary trade secrets to deliver high-sensitivity ELISA kit kits.

These high-affinity primary antibody can be used in conjunction with secondary antibodies to examine SKAP2 expression in various tissues or cells. These secondary antibodies provide solid answers and greater data. Dual labeling is a way to examine the protein levels of samples, and to identify disease markers. The combination of primary antibodies and secondary antibodies makes it easier to identify more specific targets and confirm better results.