Homeobox protein SIX6 Antibodies

Homeobox protein SIX6 (SIX6)

May be involved in eye development. .

Gene Information

Human
Gene Name:	SIX6
Uniprot:	O95475
Entrez:	4990

Family

Belongs to:
SIX/Sine oculis homeobox family

Alternative Names

homeobox protein SIX6; Homeodomain protein OPTX2; MCOPCT2; Optic homeobox 2; OPTX2; sine oculis homeobox (Drosophila) homolog 6; sine oculis homeobox homolog 6 (Drosophila); Sine oculis homeobox homolog 6; SIX homeobox 6; Six9

Molecular Weight

Mass (kDA):
27.687 kDA

Genomic Context

Human
Location:	14q23.1
Sequence:	14; NC_000014.9 (60509146..60512850)

Tissue Specificity

Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.

Subcellular Localizations

Nucleus.

Diseases

• Pituitary Diseases
• Anophthalmos
• Microphthalmos
• Haploinsufficiency
• Glaucoma
• Cataract
• Chromosomal Translocation
• Glaucoma, Open-angle
• Abnormal Degeneration
• Congenital Ocular Coloboma (disorder)
• Primary Open Angle Glaucoma
• Branchio-oto-renal Syndrome

• Dwarfism
• Congenital Abnormality
• Precursor T-cell Lymphoblastic Leukemia-lymphoma
• Holoprosencephaly
• Overlying Behavior
• Hyperplasia
• Polydactyly

Pathways

• Eye Development
• Cell Proliferation
• Forebrain Development
• Secretion
• Cell Adhesion
• Developmental Process
• Brain Development
• Neurogenesis
• Cell Fate Determination
• Pigmentation
• Inner Ear Development
• Virulence
• Eye Morphogenesis

• Circadian Behavior
• Reverse Transcription
• System Development
• Translation
• Cell Differentiation
• Epithelium Development
• Transdifferentiation

PTMs

• Phosphoprotein

Research Areas

• Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIX6

Boster Bio: Best Uses Of The SIX6 Marker

If you are looking for a new tool to aid your scientific research, it is possible that you are wondering about its best uses. This article will explain more about Boster Bio's SIX6 Marker: Best Uses and Benefits. We will also provide some tips and background information about Steven Boster. We'll cover the main benefits and applications of the SIX6 marker, as well as some tips for optimizing your use of this tool.

Benefits

The SIX6 marker, which is highly expressed by the pituitary gland, hypothalamus, and pituitary gland, is used in distinguishing bonafide retina cells, from their precursors. The pituitary gland, hypothalamus and hypothalamus also express the SIX6 marker. Moreover, SIX6 expression has been observed in pituitary-like organoids. The SIX6/GFP dual reporter iPSC line enables the researcher to distinguish bona fide retina cell lines from iPSCs taken from other tissues.

The SIX6 Gene is also expressed elsewhere, including in organoids such the hypothalamus. SIX6 is associated with higher levels in neurotrophinA protein in organoids. In addition, it is associated with the onset of aging. SIX6 is therefore important in the diagnosis and treatment of Parkinson's disease as well as Alzheimer's. To further validate this marker's function in the development of diseases, more research is needed.

The SIX6 Gene has many applications in research, including the detection and identification of organoids. This gene is particularly useful when identifying organoids inside optic vesicles. It is also useful when studying retinal tumours. The SIX6 mark inhibits the expressions of WNT and SH. The SIX6 marker can also be used to detect malignant tumors and imaging brain tumors.

Applications

The dual color reporter SIX6–GFP can be used for imaging optic organoids. It is also useful for distinguishing tissues based on their fluorescence. Both the SIX6- and POU4F2 markers were highly expressed in the retina. These results suggest that the SIX6 Marker could be used to identify brain structures. Below are several examples of the SIX6 Marker.

The SIX6 Marker, which was used in a study to label the entire retina, detected the strongest signals in the outer neuroblast. POU4F2 was localized in the inner layer of the retina near the nerve fibre layer. Both markers were immunostained by ISL1, but the results showed the SIX6 marker labelled both the retina and non-retina groups. These results are a significant step forward in the development and testing of new therapies and drugs for the eye.

History of Steven Boster

His life and legacy of Steve Boster are well documented. Steve Boster was a longtime retailer sales manager who was born in Joliet (IL) on June 6, 1932. He is also a Concordia Hall member in Staunton (VA). His two daughters, Natosha and Crystal Peck, six grandchildren, four siblings, and many nieces and nephews are his survivors. This article will be revised as Steve's legacy is documented.

His love for his family was unwavering. He was proud to be a father and loved his family with all his heart. His love for auto racing and sports made him the first person to call if his vehicle broke down in the middle of the night. He showed up for appointments in below-freezing weather. His generosity extended to his friends and family and he treated them like he was a member of his family. If you want to learn more about Steve's life, read on.

Optimization tips

You will need to prepare the sample for experiments using the SIX6 mark. This will ensure that there are no dead cells in your final suspension. Additionally to cell-separating solutions, you will also need a sieving solution to remove debris. Boster Bio's flow-cytometry guide will give you optimization and troubleshooting tips. This article provides information on sample preparation and tips for using the SIX6 marker.