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Homeobox protein SIX4 Antibodies
AND Six4 ELISA kits, Homeobox protein SIX4 Proteins
Many biological assays use antibodies to detect Homeobox protein SIX4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homeobox protein SIX4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homeobox protein SIX4 antibodies...
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Six4 Overview
Facts about Homeobox protein SIX4.
Homeobox protein SIX4 (Six4)
Transcriptional regulator which can behave as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and from a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of this muscle-specific genes enhancer (PubMed:14966291).
Acts synergistically with SIX1 to regulate target genes involved in creation of different organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Six4 |
| Uniprot: | Q61321 |
| Entrez: | 20474 |
Family
| Belongs to: |
|---|
| SIX/Sine oculis homeobox family |
Alternative Names
AREC3; homeobox protein SIX4; MGC119450; MGC119452; MGC119453; sine oculis homeobox (Drosophila) homolog 4; sine oculis homeobox homolog 4 (Drosophila); Sine oculis homeobox homolog 4; SIX homeobox 4
Molecular Weight
Mass (kDA):
82.263 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 12|12 C3 |
| Sequence: | 12; |
Tissue Specificity
Mainly expressed in the skeletal muscle (isoform 1 and isoform 2 but not isoform 3), and weakly in the heart. Also found in the retina and the distal tube of kidney. Expressed in skeletal muscle, nasal epithelium, cochlea, parathyroid and salivary gland (PubMed:11313460). Expressed in muscle satellite cells of normal and regenerating muscles (PubMed:20696153).
Diseases
- Crest Syndrome
- Pituitary Diseases
- Anophthalmos
- Myotonic Dystrophy
- Dystrophy
- Haploinsufficiency
- Hypoplasia
- Neoplasm Metastasis
- Congenital Ocular Coloboma (disorder)
- Malignant Neoplasm Of Breast
- Carcinoma
- Malignant Neoplasms
Pathways
- Eye Development
- Neurogenesis
- Somitogenesis
- Localization
- Regeneration
- Virulence
- Gonad Development
- Myoblast Differentiation
- Myoblast Fusion
- Cell Proliferation
- Head Development
- Neural Tube Closure
- Cell Migration
PTMs
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Six4
bosterbio.com/bosterbio-gene-info-cards/Six4
References
PMID: 8628654 by Kawakami K., et al. Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development.
PMID: 9990334 by Niiya A., et al. Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development.